Evidence map›Paper›PMID 26967281›Full record

ReviewCell2016

Communication in Neural Circuits: Tools, Opportunities, and Challenges.

Talia N Lerner, Li Ye, Karl Deisseroth

Abstract readReview
In one paragraph

Review in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Sex Differences in Neural Circuits Underlying Fear Processing.Current topics in behavioral neurosciences · 2025
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Talia N LernerBioengineering Department, 318 Campus Drive, Stanford University, Stanford, CA 94305, USA.
Li YeBioengineering Department, 318 Campus Drive, Stanford University, Stanford, CA 94305, USA.
Karl DeisserothBioengineering Department, 318 Campus Drive, Stanford University, Stanford, CA 94305, USA; Psychiatry Department, 318 Campus Drive, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, 318 Campus Drive, Stanford University, Stanford, CA 94305, USA. Electronic address: deissero@stanford.edu.

Funding

The Role of Striatonigrostriatal Circuitry in Habit FormationF32MH105053 · NIMH · STANFORD UNIVERSITY · PI LERNER, TALIA NEWCOMBE · 2014 to 2015
$87k
Howard Hughes Medical InstituteNIMH NIH HHS 1F32MH105053-01NIMH NIH HHS F32 MH105053
6 · The paper itself

Abstract

Communication, the effective delivery of information, is fundamental to life across all scales and species. Nervous systems (by necessity) may be most specifically adapted among biological tissues for high rate and complexity of information transmitted, and thus, the properties of neural tissue and principles of its organization into circuits may illuminate capabilities and limitations of biological communication. Here, we consider recent developments in tools for studying neural circuits with particular attention to defining neuronal cell types by input and output information streams--i.e., by how they communicate. Complementing approaches that define cell types by virtue of genetic promoter/enhancer properties, this communication-based approach to defining cell types operationally by input/output (I/O) relationships links structure and function, resolves difficulties associated with single-genetic-feature definitions, leverages technology for observing and testing significance of precisely these I/O relationships in intact brains, and maps onto processes through which behavior may be adapted during development, experience, and evolution.

Indexed as

Neural PathwaysSignal TransductionAnimalsBrainHumansOptogeneticsProtein Interaction MapsSynapses

Identifiers

PMID26967281
PMCPMC5725393

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.