ArticleOncotarget2016
Age-related changes in the transcriptome of antibody-secreting cells.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Common factors among three types of cells aged in mice.Biogerontology · 2023Article
- Immune Memory in Aging: a Wide Perspective Covering Microbiota, Brain, Metabolism, and Epigenetics.Clinical reviews in allergy & immunology · 2022Review
- Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Hyper-metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities.Immunity & ageing : I & A · 2021Article
- Unique Transcriptome Changes in Peripheral B Cells Revealed by Comparing Age Groups From Naive or Vaccinated Mice, Including snoRNA and Cdkn2a.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Age-related factors that affect B cell responses to vaccination in mice and humans.Immunological reviews · 2020Review
- Age-related changes in B cell metabolism.Aging · 2019Article
- TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Gene expression hallmarks of cellular ageing.Biogerontology · 2018Review
- Article
- Transcriptional Signatures of Aging.Journal of molecular biology · 2017Review
- Endoplasmic reticulum proteostasis impairment in aging.Aging cell · 2017Review
- Commentary: XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity.Frontiers in aging neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
We analyzed age-related defects in B cell populations from young and aged mice. Microarray analysis of bone marrow resident antibody secreting cells (ASCs) showed significant changes upon aging, affecting multiple genes, pathways and functions including those that play a role in immune regulation, humoral immune responses, chromatin structure and assembly, cell metabolism and the endoplasmic reticulum (ER) stress response. Further analysis showed upon aging defects in energy production through glucose catabolism with reduced oxidative phosphorylation. In addition aged B cells had increased levels of reactive oxygen-species (ROS), which was linked to enhanced expression of the co-inhibitor programmed cell death (PD)-1.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.