Evidence map›Paper›PMID 26967229›Full record

ReviewJournal of Alzheimer's disease : JAD2016

Microbes and Alzheimer's Disease.

Ruth F Itzhaki, Richard Lathe, Brian J Balin, Melvyn J Ball, Elaine L Bearer, Heiko Braak, Maria J Bullido, Chris Carter, Mario Clerici, S Louise Cosby and 23 more

Abstract readReview
In one paragraph

Review in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 300 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
300citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

300 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Analysis the Link between Periodontal Diseases and Alzheimer's Disease: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. Article
  9. Immune boosting to combat Alzheimer's disease: Position statement.Journal of Alzheimer's disease : JAD · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Can we refute a role for infections in Alzheimer's disease pathogenesis?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  19. Allele-specific splicing modulates protein isoforms and Alzheimer's risk.bioRxiv : the preprint server for biology · 2026
    Article
  20. Review

240 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Ruth F ItzhakiFaculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK.
Richard LatheDivision of Infection and Pathway Medicine, University of Edinburgh, Little France, Edinburgh, UK.
Brian J BalinCenter for Chronic Disorders of Aging, Philadelphia College of Osteopathic Medicine, Philadelphia, USA.
Melvyn J BallDepartment of Pathology (Neuropathology), Oregon Health and Science University, Portland, OR, USA.
Elaine L BearerDepartment of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Heiko BraakClinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany.
Maria J BullidoCentro de Biologia Molecular 'Severo Ochoa' (CSIC-UAM), Universidad Autonoma de Madrid, and Centro de Investigacion en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Chris CarterPolygenic Pathways, Hastings, East Sussex, UK.
Mario ClericiUniversity of Milano and IRCCS SM Nascente, Don C Gnocchi Foundation, Milan, Italy.
S Louise CosbyCentre for Infection and Immunity, Medical Biology Centre, Queen's University, Belfast, UK.
Kelly Del TrediciClinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany.
Hugh FieldQueens' College, Cambridge, UK.
Tamas FulopDepartment of Medicine, Division of Geriatrics, Université de Sherbrooke, Sherbrooke, PQ, Canada.
Claudio GrassiInstitute of Human Physiology, Medical School, Universitá Cattolica, Rome; San Raffaele Pisana Scientific Institute for Research, Hospitalization, and Health Care, Rome, Italy.
W Sue T GriffinDepartment of Geriatrics, University of Arkansas for Medical Sciences, and Geriatric Research, Education, and Clinical Center, Little Rock, AR, USA.
Jürgen HaasDivision of Infection and Pathway Medicine, University of Edinburgh, Little France, Edinburgh, UK.
Alan P HudsonDepartment of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI, USA.
Angela R KamerNYU College of Dentistry, Department of Periodontology and Implant Dentistry, New York, NY, USA.
Douglas B KellSchool of Chemistry, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Federico LicastroDepartment of Experimental, Diagnostic, and Specialty Medicine, School of Medicine, University of Bologna, Bologna, Italy.
Luc LetenneurINSERM, Université de Bordeaux, Bordeaux, France.
Hugo LövheimDepartment of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.
Roberta MancusoDon Gnocchi Foundation ONLUS, Milan, Italy.
Judith MiklossyPrevention Alzheimer International Foundation, International Alzheimer Research Center, Martigny-Croix, Switzerland.
Carola OtthInstitute of Clinical Microbiology, Faculty of Medicine, Austral University of Chile, Valdivia, Chile.
Anna Teresa PalamaraDepartment of Public Health and Infectious Diseases, Institute Pasteur Cenci Bolognetti Foundation, Sapienza University of Rome; San Raffaele Pisana Scientific Institute for Research, Hospitalization, and Health Care, Rome, Italy.
George PerryCollege of Sciences, University of Texas at San Antonio, San Antonio, TX, USA.
Christopher PrestonInstitute of Virology, Glasgow, UK.
Etheresia PretoriusApplied Morphology Research Centre, Department of Physiology, Faculty of Health Sciences, University of Pretoria, Arcadia, South Africa.
Timo StrandbergHelsinki University Hospital and University of Helsinki; University of Oulu, Centre of Life Course Health Research, Oulu, Finland.
Naji TabetDivision of Old Age Psychiatry, Brighton and Sussex Medical School, Brighton, UK.
Simon D Taylor-RobinsonSt Mary's Hospital, Imperial College London, London, UK.
Judith A Whittum-HudsonDepartments of Immunology and Microbiology, Internal Medicine (Rheumatology), and Ophthalmology, Wayne State University School of Medicine, Detroit, MI, USA.

Funding

RCMI Center for Interdiscplinary Health Research CIHRG12MD007591 · NIMHD · UNIVERSITY OF TEXAS SAN ANTONIO · PI PERRY, GEORGE · 2012 to 2016
$10.4M
Live imaging of brain circuitry in mouse models of PTSDR01MH096093 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BEARER, ELAINE L · 2012 to 2016
$2.8M
Using Transport to Map the BrainR01NS062184 · NINDS · UNIVERSITY OF NEW MEXICO · PI BEARER, ELAINE L · 2009 to 2010
$1.5M
Molecular mechanisms of anterograde transportR01NS046810 · NINDS · BROWN UNIVERSITY · PI BEARER, ELAINE L · 2004 to 2007
$1.1M
NIMHD NIH HHS G12 MD007591NIMH NIH HHS R01 MH096093NINDS NIH HHS R01 NS046810NINDS NIH HHS R01 NS062184
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MicrobiotaAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainCommunicable DiseasesHumansAmyloid beta-Peptides

Identifiers

PMID26967229
PMCPMC5457904

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.