ArticleJournal of Alzheimer's disease : JAD2016
The Vanderbilt Memory & Aging Project: Study Design and Baseline Cohort Overview.
Article in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- SCD-plus features and AD biomarkers in cognitively unimpaired samples: A meta-analytic approach for nine cohort studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Associations between cerebrospinal fluid markers and cognition in ageing and dementia: A systematic review.The European journal of neuroscience · 2022Pooled it
- Arterial Spin Labeling Hemodynamic Indices Relate to Cognitive and Small Vessel Disease Trajectories Over 11 Years.Stroke · 2026Article
- The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Lower cardiac output is a risk factor for faster cerebral atrophy over a 11-year follow-up period in APOE-ε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- High-fat diet is associated with accelerated gray matter atrophy in cognitively unimpaired older adults but slower atrophy in individuals with existing mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Plasma von Willebrand Factor and ADAMTS13 Interact WithJournal of the American Heart Association · 2026Article
- Is correction for gradient nonlinearity necessary in a brain diffusion tensor MRI clinical study?PloS one · 2026Article
- Development of a web platform to advance data-driven recruitment for ADRD research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The association between poor sleep health and Alzheimer's disease structural neuroimaging biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries.JAMA network open · 2025Article
- Scalable, reproducible, and cost-effective processing of large-scale medical imaging datasets.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Brain age identification from diffusion MRI synergistically predicts neurodegenerative disease.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Learning disentangled representations to harmonize connectome network measures.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cognitive status and demographics modify the association between subjective cognition and amyloid.Annals of clinical and translational neurology · 2024Article
- Free-water: A promising structural biomarker for cognitive decline in aging and mild cognitive impairment.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Elevated protease-activated receptor 4 (PAR4) gene expression in Alzheimer's disease predicts cognitive decline.Neurobiology of aging · 2024Article
- Sex, racial, andbioRxiv : the preprint server for biology · 2024Article
- Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology.Molecular neurodegeneration · 2024Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundVascular health factors frequently co-occur with Alzheimer's disease (AD). A better understanding of how systemic vascular and cerebrovascular health intersects with clinical and pathological AD may inform prevention and treatment opportunities.
objectiveTo establish the Vanderbilt Memory & Aging Project, a case-control longitudinal study investigating vascular health and brain aging, and describe baseline methodology and participant characteristics.
methodsFrom September 2012 to November 2014, 335 participants age 60- 92 were enrolled, including 168 individuals with mild cognitive impairment (MCI, 73±8 years, 41% female) and 167 age-, sex-, and race-matched cognitively normal controls (NC, 72±7 years, 41% female). At baseline, participants completed a physical and frailty examination, fasting blood draw, neuropsychological assessment, echocardiogram, cardiac MRI, and brain MRI. A subset underwent 24-hour ambulatory blood pressure monitoring and lumbar puncture for cerebrospinal fluid (CSF) collection.
resultsAs designed, participant groups were comparable for age (p = 0.31), sex (p = 0.95), and race (p = 0.65). MCI participants had greater Framingham Stroke Risk Profile scores (p = 0.008), systolic blood pressure values (p = 0.008), and history of left ventricular hypertrophy (p = 0.04) than NC participants. As expected, MCI participants performed worse on all neuropsychological measures (p-values < 0.001), were more likely to be APOEɛ4 carriers (p = 0.02), and had enhanced CSF biomarkers, including lower Aβ42 (p = 0.02), higher total tau (p = 0.004), and higher p-tau (p = 0.02) compared to NC participants.
conclusionDiverse sources of baseline and longitudinal data will provide rich opportunities to investigate pathways linking vascular and cerebrovascular health, clinical and pathological AD, and neurodegeneration contributing to novel strategies to delay or prevent cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.