ArticleJAMA otolaryngology-- head & neck surgery2016
Depression-Specific Outcomes After Treatment of Chronic Rhinosinusitis.
Article in JAMA otolaryngology-- head & neck surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Depression and anxiety in empty nose syndrome: A systematic review and Meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- Prevalence and predictors of depression and anxiety in patients with chronic rhinosinusitis: a systematic review and meta-analysis.BMJ open · 2024Pooled it
- Sino-Nasal outcome test-22 outcomes after sinus surgery: A systematic review and meta-analysis.The Laryngoscope · 2018Pooled it
- Burden of illness: A systematic review of depression in chronic rhinosinusitis.American journal of rhinology & allergy · 2016Pooled it
- Sleep in disease: inflammation and chronic rhinosinusitis.Neurobiology of sleep and circadian rhythms · 2025Article
- Effect of Hormone Replacement Therapy on Chronic Rhinosinusitis Management.The Laryngoscope · 2024Article
- Chronic rhinosinusitis with and without nasal polyps and asthma: Omalizumab improves residual anxiety but not depression.Clinical and translational allergy · 2021Article
- Diagnosis and Management of Depression in CRS: A Knowledge, Attitudes and Practices Survey.International archives of otorhinolaryngology · 2021Article
- Effect of Functional Endoscopic Sinus Surgery on Outcomes in Chronic Rhinosinusitis.Current allergy and asthma reports · 2020Review
- Clinical Research Needs for the Management of Chronic Rhinosinusitis with Nasal Polyps in the New Era of Biologics: A National Institute of Allergy and Infectious Diseases Workshop.The journal of allergy and clinical immunology. In practice · 2020Review
- [Assessment of nasal specific symptoms and psychological dysfunction in patients with chronic rhinosinusitis before and after surgery].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Article
- Longitudinal improvement in nasal obstruction symptoms of chronic rhinosinusitis directly associates with improvement in mood.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Observational
- Correlation between systemic inflammatory response and quality of life in patients with chronic rhinosinusitis.International forum of allergy & rhinology · 2019Observational
- The SNOT-22 factorial structure in European patients with chronic rhinosinusitis: new clinical insights.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Article
- Impact of sinonasal disease on depression, sleep duration, and productivity among adults in the United States.Laryngoscope investigative otolaryngology · 2017Article
- Association of olfactory dysfunction in chronic rhinosinusitis with economic productivity and medication usage.International forum of allergy & rhinology · 2017Article
- Does Managing Patients With Chronic Rhinosinusitis Improve Their Depression Score? Prospective Study.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeArticle
- Investigation of the Value of T 2 Mapping in the Prediction of Eosinophilic Chronic Rhinosinusitis With Nasal Polyps.Journal of computer assisted tomographyArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
importanceDepression is frequently undiagnosed in patients with chronic rhinosinusitis (CRS) and affects quality of life, productivity, and health care use.
objectiveTo examine depression-specific outcomes after medical or surgical treatment of CRS. DESIGN, SETTING, AND
participantsA multi-institutional, prospective study of patients with refractory CRS treated at tertiary academic rhinology centers was performed from March 1, 2011, to November 1, 2015. Data analysis was performed from October 1, 2015, to November 1, 2015.
interventionsPatients self-selected to undergo continued medical management or endoscopic sinus surgery for refractory CRS. MAIN OUTCOMES AND MEASURES: Patients completed the 22-item Sinonasal Outcome Test (SNOT22), Rhinosinusitis Disability Index (RSDI), Pittsburgh Sleep Quality Index (PSQI), and missed productivity and medication use questionnaires before and at least 6 months after treatment. Computed tomography and endoscopy scoring were performed with reviewers masked to patient-reported data. Depression-specific outcomes were recorded using the 2-item Patient Health Questionnaire (PHQ2).
resultsBaseline data were available on 685 patients, with 167 (24.4%) having depression according to the PHQ2 scores. The mean (SD) age of the patients was 50.5 (15.0) years, and 332 (48.4%) were male. Revision surgery status was the only baseline factor associated with depression (53.9% vs 38.0%, P < .001). Patients with depression had worse baseline SNOT22 (mean, 64.5 vs 47.6), PSQI (mean, 12.8 vs 8.4), productivity (mean, 22.8 vs 5.2 days missed), and medication use scores for oral antibiotics (mean, 23.8 vs 14.8) and oral corticosteroids (mean, 17.8 vs 9.9) (P < .001 for all). Medical and surgical treatments had similar outcomes for patients with depression with mean improvement in the PHQ2 scores from 3.96 to 1.91 (P < .001), and 110 of 167 patients (65.9%) categorized as having depression at baseline were categorized as not having depression after treatment. Improvements in the PHQ2 scores were associated with improvements in the SNOT22, PSQI, oral antibiotic use, and productivity scores (P ≤ .001 for all). CONCLUSIONS AND RELEVANCE: Depression is a common comorbidity in patients with CRS and affects numerous quality-of-life and health care outcomes. There are few objective baseline factors to aid physicians in identifying depression in patients with CRS. Medical and surgical treatments for CRS improve depression and related clinical outcomes.
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