ArticlePloS one2016
Multicentre Double-Blind Placebo-Controlled Food Challenge Study in Children Sensitised to Cashew Nut.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07158619 (Evaluation of the Acquisition of Sustained Unresponsiveness to Cashew Nut Protein Following Oral Allergen-Specific Immunotherapy - Long-Term Follow-Up of Patients From the RCT "Efficacy of Cashew Nut Protein Immunotherapy), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Acquisition of Sustained Unresponsiveness to Cashew Nut Protein Following Oral Allergen-Specific Immunotherapy - Long-Term Follow-Up of Patients From the RCT "Efficacy of Cashew Nut Protein Immunotherapy: A Protocol of a Single-Center Randomized Controlled Trial in the Pediatric Population" (NCT06328504)
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Peanut Can Be Used as a Reference Allergen for Hazard Characterization in Food Allergen Risk Management: A Rapid Evidence Assessment and Meta-Analysis.The journal of allergy and clinical immunology. In practice · 2022Pooled it
- Use of multiple epinephrine doses in anaphylaxis: A systematic review and meta-analysis.The Journal of allergy and clinical immunology · 2021Pooled it
- Diagnosing IgE-mediated food allergy: How to apply the latest guidelines in clinical practice.The journal of allergy and clinical immunology. Global · 2025Article
- Anaphylaxis due to cashew nut allergy associated with acute pancreatitis without abdominal pain: a case report.Journal of rural medicine : JRM · 2025Article
- A Growing Concern for Cashew and an Unexpected Risk From Almonds: Data From the Anaphylaxis Registry.Allergy · 2025Article
- Article
- Frozen Section of Placental Membranes and Umbilical Cord: A Valid Diagnostic Tool for Early-Onset Neonatal Sepsis Management.Diagnostics (Basel, Switzerland) · 2024Article
- Vegan diets from an allergy point of view - Position paper of the DGAKI working group on food allergy.Allergologie select · 2023Article
- Recent advances in diagnosing and managing nut allergies with focus on hazelnuts, walnuts, and cashew nuts.The World Allergy Organization journal · 2022Review
- Patterns of Clinical Reactivity in a Danish Cohort of Tree Nut Allergic Children, Adolescents, and Young Adults.Frontiers in allergy · 2022Article
- A remarkable food allergy in children: cashew nut allergy.Turkish archives of pediatrics · 2021Article
- Identification and in silico bioinformatics analysis of PR10 proteins in cashew nut.Protein science : a publication of the Protein Society · 2020Article
- Parental and child factors associated with inhalant and food allergy in a population-based prospective cohort study: the Generation R Study.European journal of pediatrics · 2019Article
- Cashew Nut Allergy: Clinical Relevance and Allergen Characterisation.Clinical reviews in allergy & immunology · 2019Review
- Clinical presentation of cashew nut allergy in a paediatric cohort attending an allergy clinic in the West of Ireland.Irish journal of medical science · 2019Article
- Innovation in Food Challenge Tests for Food Allergy.Current allergy and asthma reports · 2018Review
- Cashew nut allergy in Singaporean children.Asia Pacific allergy · 2018Article
- Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy.Clinical and translational allergy · 2017Article
- Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children.Clinical and translational allergy · 2017Article
- Self-Perceived Food Intolerances Are Common and Associated with Clinical Severity in Childhood Irritable Bowel Syndrome.Journal of the Academy of Nutrition and Dietetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies with a limited number of patients have provided indications that cashew-allergic patients may experience severe allergic reactions to minimal amounts of cashew nut. The objectives of this multicentre study were to assess the clinical relevance of cashew nut sensitisation, to study the clinical reaction patterns in double-blind placebo-controlled food challenge tests and to establish the amount of cashew nuts that can elicit an allergic reaction. METHODS AND
findingsA total of 179 children were included (median age 9.0 years; range 2-17 years) with cashew nut sensitisation and a clinical history of reactions to cashew nuts or unknown exposure. Sensitised children who could tolerate cashew nuts were excluded. The study included three clinical visits and a telephone consultation. During the first visit, the medical history was evaluated, physical examinations were conducted, blood samples were drawn and skin prick tests were performed. The children underwent a double-blind placebo-controlled food challenge test with cashew nut during the second and third visits. The study showed that 137 (76.5%) of the sensitised children suspected of allergy to cashew nut had a positive double-blind placebo-controlled food challenge test, with 46% (63) manifesting subjective symptoms to the lowest dose of 1 mg cashew nut protein and 11% (15) developing objective symptoms to the lowest dose. Children most frequently had gastro-intestinal symptoms, followed by oral allergy and skin symptoms. A total of 36% (49/137) of the children experienced an anaphylactic reaction and 6% (8/137) of the children were treated with epinephrine.
conclusionThis prospective study demonstrated a strikingly high percentage of clinical reactions to cashew nut in this third line population. Severe allergic reactions, including anaphylaxis requiring epinephrine, were observed. These reactions were to minimal amounts of cashew nut, demonstrated the high potency of this allergens.
trial registrationwww.ncbi.nlm.nih.gov/pubmed NTR3572.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.