Evidence map›Paper›PMID 26966636›Full record

ArticleJournal of nanomedicine & nanotechnology2015

Cardiac Ischemia Reperfusion Injury Following Instillation of 20 nm Citrate-capped Nanosilver.

N A Holland, D P Becak, Jonathan H Shannahan, J M Brown, S A Carratt, Lsv Winkle, K E Pinkerton, C M Wang, P Munusamy, Don R Baer and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanomedicine & nanotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  9. Oral administration of TiOParticle and fibre toxicology · 2022
    Article
  10. Article
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  12. Article
  13. Animal models used in the research of nanoparticles for cardiovascular diseases.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2021
    Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

N A HollandDepartment of Physiology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA.
D P BecakDepartment of Physiology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA.
Jonathan H ShannahanDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, USA.
J M BrownDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, USA.
S A CarrattDepartment of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California at Davis, Davis, California, USA.
Lsv WinkleDepartment of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California at Davis, Davis, California, USA.
K E PinkertonDepartment of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California at Davis, Davis, California, USA.
C M WangPacific Northwest National Laboratory, EMSL, Richland, USA.
P MunusamyPacific Northwest National Laboratory, EMSL, Richland, USA.
Don R BaerPacific Northwest National Laboratory, EMSL, Richland, USA.
S J SumnerRTI International, Discovery Sciences, Research Triangle Park, USA.
T R FennellRTI International, Discovery Sciences, Research Triangle Park, USA.
R M LustDepartment of Physiology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA.
C J WingardDepartment of Physiology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA.
East Carolina University · USUniversity of Montana · US

Funding

Synthesis and Characterization CoreU19ES019525 · NIEHS · RESEARCH TRIANGLE INSTITUTE · PI FENNELL, TIMOTHY RAYMOND · 2010 to 2014
$6.3M
Project 3: Dosimetry and Structure-Activity Relationships for Nanomaterial Risk AU19ES019544 · NIEHS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI THRALL, BRIAN · 2010 to 2014
$6.0M
Engineered Nanomaterials: Linking Physical and Chemical Properties to BiologyU01ES020127 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PINKERTON, KENT ED · 2010 to 2014
$2.5M
Cardio-vascular Impact of Inhaled Multi-wall Carbon NanotubesR01ES016246 · NIEHS · EAST CAROLINA UNIVERSITY · PI WINGARD, CHRISTOPHER J · 2007 to 2010
$1.4M
NIEHS NIH HHS R01 ES016246NIEHS NIH HHS U01 ES020127NIEHS NIH HHS U19 ES019525NIEHS NIH HHS U19 ES019544
6 · The paper itself

Abstract

backgroundSilver nanoparticles (AgNP) have garnered much interest due to their antimicrobial properties, becoming one of the most utilized nano-scale materials. However, any potential evocable cardiovascular injury associated with exposure has not been reported to date. We have previously demonstrated expansion of myocardial infarction after intratracheal (IT) instillation of carbon-based nanomaterials. We hypothesized pulmonary exposure to Ag core AgNP induces a measureable increase in circulating cytokines, expansion of cardiac ischemia-reperfusion (I/R) injury and is associated with depressed coronary constrictor and relaxation responses. Secondarily, we addressed the potential contribution of silver ion release on AgNP toxicity.

methodsMale Sprague-Dawley rats were exposed to 200 μl of 1 mg/ml of 20 nm citrate-capped Ag core AgNP, 0.01, 0.1, 1 mg/ml Silver Acetate (AgAc), or a citrate vehicle by intratracheal (IT) instillation. One and 7 days following IT instillation the lungs were evaluated for inflammation and the presence of silver; serum was analyzed for concentrations of selected cytokines; cardiac I/R injury and coronary artery reactivity were assessed.

resultsAgNP instillation resulted in modest pulmonary inflammation with detection of silver in lung tissue and alveolar macrophages, elevation of serum cytokines: G-CSF, MIP-1α, IL-1β, IL-2, IL-6, IL-13, IL-10, IL-18, IL-17α, TNFα, and RANTES, expansion of I/R injury and depression of the coronary vessel reactivity at 1 day post IT compared to vehicle treated rats. Silver within lung tissue was persistent at 7 days post IT instillation and was associated with an elevation in cytokines: IL-2, IL-13, and TNFα and expansion of I/R injury. AgAc resulted in a concentration dependent infarct expansion and depressed vascular reactivity without marked pulmonary inflammation or serum cytokine response.

conclusionsBased on these data, IT instillation of AgNP increases circulating levels of several key cytokines, which may contribute to persistent expansion of I/R injury possibly through an impaired vascular responsiveness.

Indexed as

Coronary arteryMyocardial infarctionNanotoxicologyPulmonary exposureSerum cytokines

Identifiers

PMID26966636
PMCPMC4780684
OpenAlexW2423339258

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.