Evidence map›Paper›PMID 26966415›Full record

ArticleCurrent oncology (Toronto, Ont.)2016

Impact of oxaliplatin-induced neuropathy in patients with colorectal cancer: a prospective evaluation at a single institution.

R Dault, M P Rousseau, A Beaudoin, M A Frenette, F Lemay, M F Beauchesne

Open access · goldAbstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Long-Term and Latent Side Effects of Specific Cancer Types.The Medical clinics of North America · 2017
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

R DaultDépartement de médecine familiale, Faculté de Médecine et des Sciences de la santé, Université de Sherbrooke, Sherbrooke, QC;
M P RousseauDépartement de pharmacie, Centre Hospitalier Universitaire de Sherbrooke ( chus ), Sherbrooke, QC;
A Beaudoinchus , Faculté de Médecine et des Sciences de la santé ( fmss ), Université de Sherbrooke, Centre de recherche du chus ( cr - chus ), Sherbrooke, QC;
M A FrenetteFaculté de droit, Université de Sherbrooke, Sherbrooke, QC;
F Lemaychus , Faculté de Médecine et des Sciences de la santé ( fmss ), Université de Sherbrooke, Centre de recherche du chus ( cr - chus ), Sherbrooke, QC;
M F BeauchesneDépartement de pharmacie, chus , fmss , Université de Sherbrooke, Faculté de pharmacie, Université de Montréal, cr - chus , Sherbrooke, QC.
Université de Sherbrooke · CACentre Hospitalier Universitaire de Sherbrooke · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxaliplatin plays a major role in the treatment of colorectal cancer (crc), but is associated with the development of neuropathies. The main objective of the present prospective study was to estimate the proportion of participants with grade 1, 2, 3, or 4 peripheral sensory neuropathies according to the U.S. National Cancer Institute's Common Terminology Criteria for Adverse Events (version 4) among crc patients treated with oxaliplatin (adjuvant or metastatic, folfox or xelox regimens) at the Centre hospitalier universitaire de Sherbrooke. Among the 57 patients so treated between May 2012 and April 2013, about 60% reported grade 2 neuropathy, at maximum, during treatment. About 25% of patients had to stop treatment because of neuropathies. In a subset of patients contacted approximately 22 months after treatment cessation, neuropathies persisted in 70%. Oxaliplatin-induced neuropathy affects a significant number of crc patients and can influence the course of treatment and outcomes.

Indexed as

chemotherapy-induced peripheral neuropathyColorectal cancerneuropathyoxaliplatin

Identifiers

PMID26966415
PMCPMC4754071
OpenAlexW2280194506

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.