Evidence map›Paper›PMID 26966412›Full record

ArticleCurrent oncology (Toronto, Ont.)2016

Dosimetric and clinical toxicity comparison of critical organ preservation with three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, and RapidArc for the treatment of locally advanced cancer of the pancreatic head.

L Jin, R Wang, S Jiang, J Yue, T Liu, X Dou, K Zhu, R Feng, X Xu, D Chen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

L JinDepartment of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R.C.;; School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan, P.R.C.
R WangDepartment of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R.C.;
S JiangDepartment of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R.C.;
J YueDepartment of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R.C.;
T LiuDepartment of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R.C.;
X DouDepartment of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R.C.;
K ZhuDepartment of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R.C.;
R FengDepartment of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R.C.;
X XuDepartment of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R.C.;
D ChenDepartment of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R.C.;; School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan, P.R.C.
Y YinDepartment of Radiation Oncology, Shandong Cancer Hospital, Jinan, P.R.C.;
Shandong First Medical University · CNShandong Tumor Hospital · CNUniversity of Jinan · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe compared dosimetry and clinical toxicity for 3-dimensional conformal radiotherapy (3D-crt), intensity-modulated radiotherapy (imrt), and RapidArc (Varian Medical Systems, Palo Alto, CA, U.S.A.) in locally advanced pancreatic cancer (lapcc). We hypothesized that the technique with better sparing of organs at risk (oars) and better target dose distributions could lead to decreased clinical toxicity.

methodsThe study analyzed 280 patients with lapcc who had undergone radiotherapy. The dosimetry comparison was performed using 20 of those patients. Dose-volume histograms for the target volume and the oars were compared. The clinical toxicity comparison used the 280 patients who received radiation with 3D-crt, imrt, or RapidArc.

resultsCompared with 3D-crt, RapidArc and imrt both achieved a better conformal index, homogeneity index, V95%, and V110%. Compared with 3D-crt or imrt, RapidArc reduced the V10, V20, and mean dose to duodenum, the V20 of the right kidney, and the liver mean dose. Compared with 3D-crt, RapidArc reduced the V35, and V45 of duodenum, the mean dose to small bowel, and the V15 of right kidney. The incidences of grades 3 and 4 diarrhea (p = 0.037) and anorexia (p = 0.042) were lower with RapidArc than with 3D-crt, and the incidences of grades 3 and 4 diarrhea (p = 0.027) were lower with RapidArc than with imrt.

conclusionsCompared with 3D-crt or imrt, RapidArc showed better sparing of oars, especially duodenum, small bowel, and right kidney. Also, fewer acute grades 3 and 4 gastrointestinal toxicities were seen with RapidArc than with 3D-crt or imrt. A technique with better sparing of oars and better target dose distributions could result in decreased clinical toxicities during radiation treatment for lapcc.

Indexed as

3d-crtDosimetric comparisonsimrtorgan preservationpancreatic cancerRapidArc

Identifiers

PMID26966412
PMCPMC4754068
OpenAlexW2287976258

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.