ArticleNeuropsychiatric disease and treatment2016
A voxel-based morphometric study of age- and sex-related changes in white matter volume in the normal aging brain.
Article in Neuropsychiatric disease and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Impact of Sevoflurane Versus Propofol Anesthesia on Post-Operative Cognitive Dysfunction in Elderly Cancer Patients: A Double-Blinded Randomized Controlled Trial.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter.Nature aging · 2026Article
- Increasing interleukin-17 induced by β-Amyloid deposition is involved in early cognitive decline after sevoflurane anesthesia.Experimental brain research · 2025Article
- Functional correlation tensors in brain white matter and the effects of normal aging.Brain imaging and behavior · 2024Article
- Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Aging pattern of the brainstem based on volumetric measurement and optimized surface shape analysis.Brain imaging and behavior · 2024Article
- Article
- Can Brain Volume-Driven Characteristic Features Predict the Response of Alzheimer's Patients to Repetitive Transcranial Magnetic Stimulation? A Pilot Study.Brain sciences · 2024Article
- Dysregulated C1q and CD47 in the aging monkey brain: association with myelin damage, microglia reactivity, and cognitive decline.Frontiers in immunology · 2024Article
- Tract-based analyses of white matter in schizophrenia, bipolar disorder, aging, and dementia using high spatial and directional resolution diffusion imaging: a pilot study.Frontiers in psychiatry · 2024Article
- Interactions between the aging brain and motor task complexity across the lifespan: balancing brain activity resource demand and supply.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Resistance Training Increases White Matter Density in Frail Elderly Women.Journal of clinical medicine · 2023Article
- Aerobic exercise is associated with region-specific changes in volumetric, tensor-based, and fixel-based measures of white matter integrity in healthy older adults.Neuroimage. Reports · 2023Article
- Cognitive Aging: How the Brain Ages?Advances in experimental medicine and biology · 2023Article
- Evolutionary and genomic perspectives of brain aging and neurodegenerative diseases.Progress in brain research · 2023Article
- Unraveling the pathophysiology of schizophrenia: insights from structural magnetic resonance imaging studies.Frontiers in psychiatry · 2023Article
- Neurobiological Mechanisms of Cognitive Decline Correlated with Brain Aging.Advances in experimental medicine and biology · 2023Article
- Brain structure and working memory adaptations associated with maturation and aging in mice.Frontiers in aging neuroscience · 2023Article
- Sedentary behavior, brain-derived neurotrophic factor and brain structure in midlife: A longitudinal brain MRI sub-study of the coronary artery risk development in young adults study.Frontiers in dementia · 2023Article
- Association of white matter volume with sleep quality: a voxel-based morphometry study.Brain imaging and behavior · 2022Article
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Authors and funding
7 authors.
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Abstract
objectiveTo carry out a cross-sectional study of 187 cognitively normal Chinese adults using the voxel-based morphometry (VBM) approach to delineate age-related changes in the white matter volume of regions of interest in the brain and further analyze their correlation with age. MATERIALS AND
methodsA total of 187 cognitively normal adults were divided into the young, middle, and old age-groups. Conventional magnetic resonance imaging was performed with the Achieva 3.0 T system. Structural images were processed using VBM8 and statistical parametric mapping 8. Regions of interest were obtained by WFU PickAtlas, and all realigned images were spatially normalized.
resultsFemales showed significantly greater total white matter volume than males (t=2.36, P=0.0096, false-discovery rate [FDR] corrected). VBM demonstrated statistically significant age-related differences in white matter volume between the young age-group and the middle age-group (P<0.05, FDR corrected) and between the middle age-group and the old age-group (P<0.05, FDR corrected). No interaction was found between age and sex on white matter volume (P<0.05, FDR corrected). Logistic regression analysis revealed nonlinear correlation between total white matter volume and age (R (2)=0.124, P<0.001). White matter volume gradually increased before 40 years of age, peaked around 50 years of age, and rapidly declined after 60 years of age.
conclusionSignificant age-related differences are present in white matter volume across multiple brain regions during aging. The VBM approach may help differentiate underlying normal neurobiological aging changes of specific brain regions from neurodegenerative impairments.
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