Evidence map›Paper›PMID 26966339›Full record

ArticleThe Egyptian journal of chest diseases and tuberculosis2014

Host genome polymorphisms and tuberculosis infection: What we have to say?

Said Alfin Khalilullah, Harapan Harapan, Nabeeh A Hasan, Wira Winardi, Ichsan Ichsan, Mulyadi Mulyadi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Egyptian journal of chest diseases and tuberculosis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. The rs5743708 gene polymorphism in the TLR2 gene contributes to the risk of tuberculosis disease.International journal of clinical and experimental pathology · 2015
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Pharmacogenomics and personalized medicine · 2023
    Article
  6. Decreased classical monocytes and CD163 expression in TB patients: an indicator of drug resistance.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2018
    Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Said Alfin KhalilullahMedical Research Unit, School of Medicine Syiah Kuala University, Banda Aceh, Indonesia.
Harapan HarapanMedical Research Unit, School of Medicine Syiah Kuala University, Banda Aceh, Indonesia; Tropical Disease Center, School of Medicine Syiah Kuala University, Banda Aceh, Indonesia.
Nabeeh A HasanResearch Affiliate, Centre for Genes, Environment and Health, National Jewish Health, Denver, CO, USA; Computational Bioscience Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Wira WinardiMedical Research Unit, School of Medicine Syiah Kuala University, Banda Aceh, Indonesia; Graduate Institute of Medical Science, Taipei Medical University, Taipei, Taiwan.
Ichsan IchsanMedical Research Unit, School of Medicine Syiah Kuala University, Banda Aceh, Indonesia; Tropical Disease Center, School of Medicine Syiah Kuala University, Banda Aceh, Indonesia; Institute of Medical Microbiology and National Reference Center for Systemic Mycosis, University Medical Center Goettingen, Goettingen, Germany.
Mulyadi MulyadiPulmonology Department, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
Syiah Kuala University · IDNational Jewish Health · US

Funding

Computational Bioscience Program Training GrantT15LM009451 · NLM · UNIVERSITY OF COLORADO DENVER · PI Katherina Kechris-Mays, Arjun Krishnan · 2007 to 2026
$11.7M
NLM NIH HHS T15 LM009451
6 · The paper itself

Abstract

Several epidemiology studies suggest that host genetic factors play important roles in susceptibility, protection and progression of tuberculosis infection. Here we have reviewed the implications of some genetic polymorphisms in pathways related to tuberculosis susceptibility, severity and development. Large case-control studies examining single-nucleotide polymorphisms (SNPs) in genes have been performed in tuberculosis patients in some countries. Polymorphisms in natural resistance-associated macrophage protein 1 (NRAMP1), toll-like receptor 2 (TLR2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-1 receptor antagonist (IL-1RA), IL-10, vitamin D receptor (VDR), dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN), monocyte chemoattractant protein-1 (MCP-1), nucleotide oligomerization binding domain 2 (NOD2), interferon-gamma (IFN-γ), inducible nitric oxide synthase (iNOS), mannose-binding lectin (MBL) and surfactant proteins A (SP-A) have been reviewed. These genes have been variably associated with tuberculosis infection and there is strong evidence indicating that host genetic factors play critical roles in tuberculosis susceptibility, severity and development.

Indexed as

Gene polymorphismMycobacterium tuberculosisTuberculosis developmentTuberculosis infectionTuberculosis protectionTuberculosis susceptibility

Identifiers

PMID26966339
PMCPMC4782973
OpenAlexW2023775676

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.