Evidence map›Paper›PMID 26966237›Full record

Trial reportThorax2016

Lung function in woodsmoke-exposed Guatemalan children following a chimney stove intervention.

Amy P Heinzerling, Michael J Guarnieri, Jennifer K Mann, Janet V Diaz, Lisa M Thompson, Anaite Diaz, Nigel G Bruce, Kirk R Smith, John R Balmes

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Thorax, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Effects of Household Air Pollution (HAP) on Lung Function in Children: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Household air pollution and COPD: cause and effect or confounding by other aspects of poverty?The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
    Review
  11. Review
  12. Article
  13. Air pollution and lung function in children.The Journal of allergy and clinical immunology · 2021
    Review
  14. Review
  15. Review
  16. Lung Health in Children in Sub-Saharan Africa: Addressing the Need for Cleaner Air.International journal of environmental research and public health · 2020
    Review
  17. Article
  18. Article
  19. Article
  20. When the Fetus Is Exposed to Smoke, the Developing Lung Is Burned.American journal of respiratory and critical care medicine · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Amy P HeinzerlingDepartment of Medicine, University of California San Francisco, California, USA.
Michael J GuarnieriDepartment of Medicine, University of California San Francisco, California, USA.
Jennifer K MannDepartment of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA.
Janet V DiazDepartment of Medicine, University of California San Francisco, California, USA.
Lisa M ThompsonSchool of Nursing, University of California, San Francisco, California, USA.
Anaite DiazCenter for Health Studies, Universidad del Valle de Guatemala, Guatemala.
Nigel G BruceDepartment of Public Health and Policy, University of Liverpool, Liverpool, UK.
Kirk R SmithDepartment of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA.
John R BalmesDepartment of Medicine, University of California San Francisco, California, USA Department of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA.

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
INDOOR AIR POLLUTION AND CHILD ARI: A RANDOMIZED TRIALR01ES010178 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SMITH, KIRK R · 2001 to 2009
$4.5M
NCATS NIH HHS UL1 TR000004NIEHS NIH HHS R01 ES010178NIMHD NIH HHS L60 MD003455
6 · The paper itself

Abstract

rationaleHousehold air pollution (HAP) from solid fuel combustion is a major contributor to the global burden of disease, with considerable impact from respiratory infections in children. The impact of HAP on lung function is unknown.

objectivesThe Childhood Exposure to Respirable Particulate Matter (CRECER) prospective cohort study followed Guatemalan children who participated in the Randomised Exposure Study of Pollution Indoors and Respiratory Effects (RESPIRE) trial of a chimney stove intervention to determine the effect of early childhood HAP exposure on growth of lung function.

methodsRESPIRE households with pregnant women or infant children were randomised to receive a chimney stove at the beginning or at the end of the 18-month trial. During CRECER, a subset of these children, as well as children from households with newly installed stoves, were followed with spirometry beginning at age 5. Biomass smoke exposure was measured using personal carbon monoxide tubes. Two-stage regression models were employed to analyse associations with lung function growth. MEASUREMENTS AND MAIN

resultsLongitudinal peak expiratory flow (PEF) and FEV1 data were available for 443 and 437 children, respectively, aged 5-8 (mean follow-up 1.3 years). Decreases in PEF growth of 173 mL/min/year (95% CI -341 to -7) and FEV1 of 44 mL/year (95% CI -91 to 4) were observed with stove installation at 18 months compared with stove installation at birth in analyses adjusted for multiple covariates. No statistically significant associations were observed between personal HAP exposure and lung function.

conclusionsA significant decrease in PEF growth and a large non-significant decrease in FEV1 growth were observed with later stove installation. Additional studies including longer follow-up and cleaner stoves or fuels are needed.

Indexed as

CookingForced Expiratory Flow RatesPregnant PeopleRural PopulationAir Pollution, IndoorCarbon MonoxideChildChild, PreschoolGuatemalaHumansIncidenceParticulate MatterPeak Expiratory Flow RatePneumoniaProspective StudiesSmokeCarbon MonoxideParticulate MatterSmokeLung PhysiologyPaediatric Lung Disaese

Identifiers

PMID26966237
PMCPMC10666195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.