Evidence map›Paper›PMID 26966050›Full record

ArticleReproductive biomedicine online2016

Annexin A5 haplotype M2 is not a risk factor for recurrent spontaneous abortion in Northern Europe: is there sufficient evidence?

Arseni Markoff, Hiroki Kurahashi, Elvira Grandone, Nadja Bogdanova

Open access · hybridAbstract readComment
PubMed Publisher
In one paragraph

Article in Reproductive biomedicine online, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Arseni MarkoffInstitute of Human Genetics, University of Muenster, Vesaliusweg 12-14, 48149 Muenster, Germany. Electronic address: markoff@uni-muenster.de.
Hiroki KurahashiDivision of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
Elvira GrandoneAtherosclerosis and Thrombosis Unit, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia 71013, Italy.
Nadja BogdanovaInstitute of Human Genetics, University of Muenster, Vesaliusweg 12-14, 48149 Muenster, Germany.
University of Münster · DECasa Sollievo della Sofferenza · ITFujita Health University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The M2 haplotype of the annexin A5 gene is a well-recognized predisposition factor for recurrent spontaneous abortion (RSA). A recent publication by Nagirnaja et al. (2015) in PLoS One discusses the risk role of the M2 haplotype for RSA in cases compared with controls of North European extraction and arrives at a negative result. As a number of previous and fairly recent studies have supported the proposed involvement of the M2 haplotype in the cause of idiopathic RSA, this commentary aims to highlight problematic issues in the above publication. It is the opinion of the authors that the study by Nagirnaja et al. (2015) does not generate adequate proof of the absence of RSA risk, attributable to carriage of the M2 haplotype.

Indexed as

Promoter Regions, GeneticAbortion, HabitualAnnexin A5FemaleHumansPregnancyAnnexin A5annexin A5ANXA5M2/ANXA5recurrent miscarriagerisk factor

Identifiers

PMID26966050
OpenAlexW2277964974

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.