Evidence map›Paper›PMID 26966043›Full record

ArticleUrology2016

Diagnostic Value of Guided Biopsies: Fusion and Cognitive-registration Magnetic Resonance Imaging Versus Conventional Ultrasound Biopsy of the Prostate.

Daniel T Oberlin, David D Casalino, Frank H Miller, Richard S Matulewicz, Kent T Perry, Robert B Nadler, Shilajit Kundu, William J Catalona, Joshua J Meeks

Open access · greenAbstract readComparative Study
In one paragraph

Article in Urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Daniel T OberlinDepartment of Urology, Northwestern Feinberg School of Medicine, Chicago, IL. Electronic address: Daniel-oberlin@northwestern.edu.
David D CasalinoDepartment of Urology, Northwestern Feinberg School of Medicine, Chicago, IL.
Frank H MillerDepartment of Urology, Northwestern Feinberg School of Medicine, Chicago, IL.
Richard S MatulewiczDepartment of Urology, Northwestern Feinberg School of Medicine, Chicago, IL.
Kent T PerryDepartment of Urology, Northwestern Feinberg School of Medicine, Chicago, IL.
Robert B NadlerDepartment of Urology, Northwestern Feinberg School of Medicine, Chicago, IL.
Shilajit KunduDepartment of Urology, Northwestern Feinberg School of Medicine, Chicago, IL.
William J CatalonaDepartment of Urology, Northwestern Feinberg School of Medicine, Chicago, IL.
Joshua J MeeksDepartment of Urology, Northwestern Feinberg School of Medicine, Chicago, IL.
Northwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Targeting FOXA1-downstream pathways: a novel therapeutic strategy for castration-resistant prostate cancerP50CA180995 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ABDULKADIR, SARKI A., HUSSAIN, MAHA H · 2015 to 2025
$19.9M
NCI NIH HHS P30 CA060553NCI NIH HHS P50 CA180995
6 · The paper itself

Abstract

objectiveTo better assess the increased utilization of multiparametric magnetic resonance imaging (mpMRI) and fusion biopsy of the prostate, we compared prostate cancer detection rates among (a) men undergoing MR-ultrasound (US) fusion biopsy, (b) mpMRI cognitive-registration biopsy, and (c) conventional transrectal US-guided biopsy for the detection of prostate cancer. MATERIALS AND

methodsWe present a retrospective review of consecutive patients undergoing mpMRI of the prostate with subsequent prostate biopsy from October 2013 to September 2015. Lesions concerning for prostate cancer visualized on mpMRI were targeted with cognitive-registration or MR-US fusion biopsies. A cohort of men undergoing conventional prostate biopsy was utilized for comparison. Rates of cancer detection were compared among the 3 cohorts.

resultsA total of 231 patients underwent mpMRI-targeted biopsy (81 fusion, 150 cognitive). There was no difference in prostate specific antigen, mpMRI-defined Prostate Imaging Reporting and Data System score or number of lesions, or history of prostate cancer among the cohorts. The overall detection rate of cancer was significantly higher in the fusion cohort (48.1%) compared with both the cognitive (34.6% P = .04) and conventional (32.0%, P = .03) cohorts. Cancer detection rates were comparable in the MRI-cognitive and transrectal prostate US biopsy groups (34.6% vs 32%). MR fusion detected significantly more Gleason ≥7 cancer (61.5 vs 37.5%, P = .04) and significantly less Gleason 6 cancer (38.5 vs 62.5%, P = .04) compared with conventional biopsy.

conclusionTargeted biopsy of the prostate using MR-US fusion increased the cancer detection rate compared with both cognitive registration and conventional biopsy and was associated with detection of higher-grade cancer compared with conventional biopsy.

Indexed as

Magnetic Resonance ImagingUltrasonographyAgedCognitionHumansImage-Guided BiopsyMaleMiddle AgedProstateProstatic NeoplasmsRetrospective Studies

Identifiers

PMID26966043
PMCPMC4882086
OpenAlexW2301519626

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.