Evidence map›Paper›PMID 26966014›Full record

ArticleJournal of the American Society of Nephrology : JASN2016

Somatic Mutations Modulate Autoantibodies against Galactose-Deficient IgA1 in IgA Nephropathy.

Zhi Qiang Huang, Milan Raska, Tyler J Stewart, Colin Reily, R Glenn King, David K Crossman, Michael R Crowley, Audra Hargett, Zhixin Zhang, Hitoshi Suzuki and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  7. Immune abnormalities in IgA nephropathy.Clinical kidney journal · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 4 countries.

Zhi Qiang HuangUniversity of Alabama at Birmingham, Birmingham, Alabama.
Milan RaskaUniversity of Alabama at Birmingham, Birmingham, Alabama.
Tyler J StewartUniversity of Alabama at Birmingham, Birmingham, Alabama.
Colin ReilyUniversity of Alabama at Birmingham, Birmingham, Alabama.
R Glenn KingUniversity of Alabama at Birmingham, Birmingham, Alabama.
David K CrossmanUniversity of Alabama at Birmingham, Birmingham, Alabama.
Michael R CrowleyUniversity of Alabama at Birmingham, Birmingham, Alabama.
Audra HargettUniversity of Alabama at Birmingham, Birmingham, Alabama.
Zhixin ZhangUniversity of Nebraska Medical Center, Omaha, Nebraska.
Hitoshi SuzukiUniversity of Alabama at Birmingham, Birmingham, Alabama.
Stacy HallUniversity of Alabama at Birmingham, Birmingham, Alabama.
Robert J WyattUniversity of Tennessee Health Science Center, Memphis, Tennessee; and.
Bruce A JulianUniversity of Alabama at Birmingham, Birmingham, Alabama.
Matthew B RenfrowUniversity of Alabama at Birmingham, Birmingham, Alabama.
Ali G GharaviColumbia University, New York, New York.
Jan NovakUniversity of Alabama at Birmingham, Birmingham, Alabama; jannovak@uab.edu.
University of Alabama at Birmingham · USColumbia University · USSichuan University · CNUniversity of Tennessee Health Science Center · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
OMOP information model for eMERGE phenotypingU01HG008680 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung, GEORGE M HRIPCSAK · 2015 to 2026
$13.3M
Elucidating IgA Nephropathy through Genetic Studies of IgA1 GlycosylationR01DK082753 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GHARAVI, ALI G, NOVAK, JAN · 2009 to 2024
$8.7M
Molecular Basis of Pathogenicity of IgA1-containing Immune ComplexesR01DK078244 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAN NOVAK · 2007 to 2026
$6.0M
Training Program in Cell, Molecular, and Developmental BiologyT32GM008111 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 1985 to 2022
$5.4M
Analytical tools for the analysis of clustered O-glycans in clinical samplesR01GM098539 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RENFROW, MATTHEW B · 2011 to 2019
$2.7M
Abnormal STAT3 Signaling and Aberrant O-Glycosylation of IgA1 in IgA NephropathyK01DK106341 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI REILY, COLIN ROBERT · 2015 to 2021
$918k
Molecular Basis of Pathogenicity of IgA1-containing Immune ComplexesR56DK078244 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NOVAK, JAN · 2012 to 2012
$92k
IgA nephropathy and the role of clustered glycosylation initiation by GalNAc-transferasesF31DK109599 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEWART, TYLER J · 2016 to 2017
$68k
NCI NIH HHS P30 CA013148NHGRI NIH HHS U01 HG008680NIAID NIH HHS P30 AI027767NIDDK NIH HHS F31 DK109599NIDDK NIH HHS K01 DK106341NIDDK NIH HHS R01 DK078244NIDDK NIH HHS R01 DK082753NIDDK NIH HHS R56 DK078244NIGMS NIH HHS R01 GM098539NIGMS NIH HHS T32 GM008111
6 · The paper itself

Abstract

Autoantibodies against galactose-deficient IgA1 drive formation of pathogenic immune complexes in IgA nephropathy. IgG autoantibodies against galactose-deficient IgA1 in patients with IgA nephropathy have a specific amino-acid sequence, Y

Indexed as

Immunoglobulin AMutationAutoantibodiesGalactoseGlomerulonephritis, IGAHumansAutoantibodiesGalactoseImmunoglobulin AIgA nephropathyimmune complexesimmunology

Identifiers

PMID26966014
PMCPMC5084875
OpenAlexW2336413272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.