ArticleRespiratory research2016
Exposure to urban PM1 in rats: development of bronchial inflammation and airway hyperresponsiveness.
Article in Respiratory research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
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- Effect Modification of Heat-Related Mortality Risk by Air Pollutants in Shandong, China.The American journal of tropical medicine and hygiene · 2024Article
- Design, optimization, and evaluation of a wet electrostatic precipitator (ESP) for aerosol collection.Atmospheric environment (Oxford, England : 1994) · 2023Article
- Association between ambient cold exposure and mortality risk in Shandong Province, China: Modification effect of particulate matter size.Frontiers in public health · 2022Article
- Prenatal exposure to fine particulate matter and the risk of spontaneous preterm birth: A population-based cohort study of twins.Frontiers in public health · 2022Article
- A critical review of environmentally persistent free radical (EPFR) solvent extraction methodology and retrieval efficiency.Chemosphere · 2021Review
- Evaluation of life expectancy loss associated with submicron and fine particulate matter (PMEnvironmental science and pollution research international · 2021Article
- Are standardized diesel exhaust particles (DEP) representative of ambient particles in air pollution toxicological studies?The Science of the total environment · 2021Article
- 2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells.Molecules (Basel, Switzerland) · 2021Article
- Zebrafish irritant responses to wildland fire-related biomass smoke are influenced by fuel type, combustion phase, and byproduct chemistry.Journal of toxicology and environmental health. Part A · 2021Article
- Evaluation of a high flow rate electrostatic precipitator (ESP) as a particulate matter (PM) collector for toxicity studies.The Science of the total environment · 2020Article
- Unraveling the blood transcriptome after real-life exposure of Wistar-rats to PM2.5, PM1 and water-soluble metals in the ambient air.Toxicology reports · 2020Article
- Inhalation Exposure Analysis of Lung-Inhalable Particles in an Approximate Rat Central Airway.International journal of environmental research and public health · 2019Article
- Impact of Long-Term Exposures to Ambient PMChest · 2019Observational
- Development of a novel aerosol generation system for conducting inhalation exposures to ambient particulate matter (PM).The Science of the total environment · 2019Article
- Association of Long-term Exposure to Airborne Particulate Matter of 1 μm or Less With Preterm Birth in China.JAMA pediatrics · 2018Article
- Concentrated Ambient PMEnvironmental health perspectives · 2018Article
- Zebrafish Locomotor Responses Reveal Irritant Effects of Fine Particulate Matter Extracts and a Role for TRPA1.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral epidemiological and laboratory studies have evidenced the fact that atmospheric particulate matter (PM) increases the risk of respiratory morbidity. It is well known that the smallest fraction of PM (PM1 - particulate matter having a diameter below 1 μm) penetrates the deepest into the airways. The ratio of the different size fractions in PM is highly variable, but in industrial areas PM1 can be significant. Despite these facts, the health effects of PM1 have been poorly investigated and air quality standards are based on PM10 and PM2.5 (PM having diameters below 10 μm and 2.5 μm, respectively) concentrations. Therefore, this study aimed at determining whether exposure to ambient PM1 at a near alert threshold level for PM10 has respiratory consequences in rats.
methodsRats were either exposed for 6 weeks to 100 μg/m(3) (alert threshold level for PM10 in Hungary) urban submicron aerosol, or were kept in room air. End-expiratory lung volume, airway resistance (Raw) and respiratory tissue mechanics were measured. Respiratory mechanics were measured under baseline conditions and following intravenous methacholine challenges to characterize the development of airway hyperresponsiveness (AH). Bronchoalveolar lavage fluid (BALF) was analyzed and lung histology was performed.
resultsNo significant differences were detected in lung volume and mechanical parameters at baseline. However, the exposed rats exhibited significantly greater MCh-induced responses in Raw, demonstrating the progression of AH. The associated bronchial inflammation was evidenced by the accumulation of inflammatory cells in BALF and by lung histology.
conclusionsOur findings suggest that exposure to concentrated ambient PM1 (mass concentration at the threshold level for PM10) leads to the development of mild respiratory symptoms in healthy adult rats, which may suggest a need for the reconsideration of threshold limits for airborne PM1.
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