ArticleMolecular biology reports2016
Pig fatness in relation to FASN and INSIG2 genes polymorphism and their transcript level.
Article in Molecular biology reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 31 citations in OpenAlex.
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- Integrated multi-omics reveals potential regulatory mechanisms of meat quality.Food chemistry. Molecular sciences · 2025Article
- Meta-analysis of muscle transcriptome data identifies key genes influencing intramuscular fat content in pigs.Animal bioscience · 2025Article
- Identification ofGenes · 2024Article
- Transcriptome and Metabolome Analyses Provide Insight into the Glucose-Induced Adipogenesis in Porcine Adipocytes.Current issues in molecular biology · 2024Article
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- Differences in Muscle Lipogenic Gene Expression, Carcass Traits and Fat Deposition among Three Iberian Pig Strains Finished in Two Different Feeding Systems.Animals : an open access journal from MDPI · 2023Article
- Design of a low-density SNP panel for intramuscular fat content and fatty acid composition of backfat in free-range Iberian pigs.Journal of animal science · 2023Article
- Multi-tissue transcriptome analysis to identify candidate genes associated with weight regulation in Hanwoo cattle.Frontiers in genetics · 2023Article
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- Antioxidant and antimicrobial activities of phytonutrients as antibiotic substitutes in poultry feed.Environmental science and pollution research international · 2022Review
- The Effect of Black Pepper (Animals : an open access journal from MDPI · 2020Article
- Identification of Molecular Mechanisms Related to Pig Fatness at the Transcriptome and miRNAome Levels.Genes · 2020Article
- Identification of Differentially Expressed MicroRNAs and Their Potential Target Genes in Adipose Tissue from Pigs with Highly Divergent Backfat Thickness.Animals : an open access journal from MDPI · 2020Article
- Evaluation of SCD, ACACA and FASN Mutations: Effects on Pork Quality and Other Production Traits in Pigs Selected Based on RNA-Seq Results.Animals : an open access journal from MDPI · 2020Article
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- Analysis and preliminary validation of the molecular mechanism of fat deposition in fatty and lean pigs by high-throughput sequencing.Mammalian genome : official journal of the International Mammalian Genome Society · 2019Article
- Modulatory Effects of Breed, Feeding Status, and Diet on Adipogenic, Lipogenic, and Lipolytic Gene Expression in Growing Iberian and Duroc Pigs.International journal of molecular sciences · 2017Article
- Study on quantitative expression of PPARγ and ADRP in muscle and its association with intramuscular fat deposition of pig.SpringerPlus · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fat content and fatty acid (FA) profile influence meat quality in pigs. These parameters are important for consumers due to their preferences for healthy, high quality meat. The aim of this study was searching for polymorphisms and transcript levels of two positional and functional candidate genes, FASN and INSIG2, encoding proteins which take part in lipid metabolism. The molecular findings were analyzed in relation to fatness traits. Pigs of four commercial breeds were included: Polish Landrace (PL), Polish Large White (PLW), Duroc and Pietrain. DNA sequencing, 5'RACE technique and real time PCR and association analysis were applied. In total, 20 polymorphisms in 5'-flanking, 5'UTR and 3'UTR regions of FASN (12 novel polymorphisms) and INSIG2 (seven novel ones and one known) genes were found. Association study with fatness traits (PL n = 225, PLW n = 179) revealed that four polymorphisms (c.-2908G>A, c.-2335C>T, c.*42_43insCCCCA and c.*264A>G) of the FASN gene were associated with back fat thickness in PL and PLW. Since the polymorphisms were identified in regulatory sequences of the both genes also their transcript levels were studied in PLW (n = 23), PL (n = 22), Pietrain (n = 17) and Duroc (n = 23). The INSIG2 transcript level was positively correlated with monounsaturated FA contents in the longissimus thoracis et lumborum muscle. Several correlations were also found between three polymorphisms (c.*264A>G and c.-2335C>T in FASN, and c.-5527C>G in INSIG2) and the FA content. Our study showed that the FASN gene is a promising marker for subcutaneous fat tissue accumulation, while INSIG2 is a promising marker for FA composition.
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