Evidence map›Paper›PMID 26965843›Full record

Observational studyClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2016

Total Pancreatectomy With Islet Autotransplantation Improves Quality of Life in Patients With Refractory Recurrent Acute Pancreatitis.

Melena D Bellin, Tossapol Kerdsirichairat, Gregory J Beilman, Ty B Dunn, Srinath Chinnakotla, Timothy L Pruett, David R Radosevich, Sarah J Schwarzenberg, David E R Sutherland, Mustafa A Arain and 1 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Review
  14. Antioxidant Therapy in Pancreatitis.Antioxidants (Basel, Switzerland) · 2021
    Review
  15. Article
  16. Identification and management of pancreas divisum.Expert review of gastroenterology & hepatology · 2019
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Melena D BellinDepartments of Medicine, Pediatrics, and Surgery, University of Minnesota, Minneapolis, Minnesota.
Tossapol KerdsirichairatDepartments of Medicine, Pediatrics, and Surgery, University of Minnesota, Minneapolis, Minnesota.
Gregory J BeilmanDepartments of Medicine, Pediatrics, and Surgery, University of Minnesota, Minneapolis, Minnesota.
Ty B DunnDepartments of Medicine, Pediatrics, and Surgery, University of Minnesota, Minneapolis, Minnesota.
Srinath ChinnakotlaDepartments of Medicine, Pediatrics, and Surgery, University of Minnesota, Minneapolis, Minnesota.
Timothy L PruettDepartments of Medicine, Pediatrics, and Surgery, University of Minnesota, Minneapolis, Minnesota.
David R RadosevichDepartments of Medicine, Pediatrics, and Surgery, University of Minnesota, Minneapolis, Minnesota.
Sarah J SchwarzenbergDepartments of Medicine, Pediatrics, and Surgery, University of Minnesota, Minneapolis, Minnesota.
David E R SutherlandDepartments of Medicine, Pediatrics, and Surgery, University of Minnesota, Minneapolis, Minnesota.
Mustafa A ArainDepartments of Medicine, Pediatrics, and Surgery, University of Minnesota, Minneapolis, Minnesota.
Martin L FreemanDepartments of Medicine, Pediatrics, and Surgery, University of Minnesota, Minneapolis, Minnesota. Electronic address: freem020@umn.edu.
University of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Sitagliptin therapy to improve outcomes after islet autotransplantation.K23DK084315 · NIDDK · UNIVERSITY OF MINNESOTA · PI BELLIN, MELENA D. · 2010 to 2014
$816k
NCATS NIH HHS UL1 TR000114NIDDK NIH HHS K23 DK084315
6 · The paper itself

Abstract

BACKGROUND &

aimsTherapeutic options are limited for patients with recurrent acute pancreatitis who have intractable symptoms despite maximal endoscopic and medical treatment, but equivocal or no morphologic or functional evidence of chronic pancreatitis. We performed a prospective observational cohort study to determine the efficacy of total pancreatectomy with islet autotransplantation (TPIAT) for these patients.

methodsWe collected data from all patients undergoing TPIAT at the University of Minnesota from 2007 through 2013; 49 patients (42 female; mean age, 32.8 ± 7.8 years) had a diagnosis of recurrent acute pancreatitis not provoked by intervention, with negative or equivocal findings from nondiagnostic imaging or pancreatic function tests for chronic pancreatitis, and intractable pain between episodes. Data on insulin use, narcotic requirements, pain scores, and health-related quality of life were collected before TPIAT; 3 months, 6 months, and 1 year afterward; and then yearly.

resultsAll 49 patients studied required narcotics before TPIAT (45 daily users and 4 intermittent users); 2 had insulin-treated diabetes. At 1 year after TPIAT, 22 out of 48 patients (46%) reported no use of narcotic pain medications (P < .001 vs baseline). Health-related quality of life score, measured by the physical and mental component summary score, increased by approximately 1 standard deviation from the population mean (P < .001 for the physical component summary; P = .019 for the mental component summary). At 1 year after TPIAT, 21 out of 48 patients (45%) were insulin independent; their mean percent glycosylated hemoglobin A1c at 1 year after TPIAT was 6.0% ± 0.9% (5.2% ± 0.6% pre-TPIAT).

conclusionsPatients with recurrent acute pancreatitis but lacking clear chronic pancreatitis benefit from TPIAT, with outcomes similar to those previously described for patients with chronic pancreatitis (improved quality of life and reduced narcotic use). For these patients who have otherwise limited surgical treatment options, TPIAT can be considered when medical and endoscopic therapies have failed.

Indexed as

Genomic IslandsTransplantation, AutologousAdolescentAdultAgedAged, 80 and overFemaleHospitals, UniversityHumansMaleMiddle AgedMinnesotaPancreatectomyPancreatitis, Acute NecrotizingProspective StudiesQuality of Lifeclinical trialCPHRQLpancreas

Identifiers

PMID26965843
PMCPMC5538725
OpenAlexW2293136377

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.