Evidence map›Paper›PMID 26965720›Full record

ArticleDiabetes care2016

Metabolic Syndrome Components Are Associated With Symptomatic Polyneuropathy Independent of Glycemic Status.

Brian C Callaghan, Rong Xia, Mousumi Banerjee, Nathalie de Rekeneire, Tamara B Harris, Anne B Newman, Suzanne Satterfield, Ann V Schwartz, Aaron I Vinik, Eva L Feldman and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 5 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 5 syntheses or guidelines pooled it, 207 citations in OpenAlex.

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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Brian C CallaghanDepartment of Neurology, University of Michigan, Ann Arbor, MI bcallagh@med.umich.edu.
Rong XiaSchool of Public Health, University of Michigan, Ann Arbor, MI.
Mousumi BanerjeeSchool of Public Health, University of Michigan, Ann Arbor, MI.
Nathalie de RekeneireUniversity Bordeaux, ISPED, Centre INSERM U1219-Epidemiologie-Biostatistique, Bordeaux, France.
Tamara B HarrisNational Institute on Aging, Bethesda, MD.
Anne B NewmanSchool of Public Health, University of Pittsburgh, Pittsburgh, PA.
Suzanne SatterfieldSchool of Public Health, University of Pittsburgh, Pittsburgh, PA.
Ann V SchwartzDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
Aaron I VinikStrelitz Diabetes Research Institute, Norfolk, VA.
Eva L FeldmanDepartment of Neurology, University of Michigan, Ann Arbor, MI.
Elsa S StrotmeyerSchool of Public Health, University of Pittsburgh, Pittsburgh, PA.
Health ABC Study
University of Tennessee Health Science Center · USUniversity of Michigan–Ann Arbor · USNational Institute on Aging · USUniversity of California, San Francisco · US

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Tissue-Specific Metabolic Reprogramming in Diabetic ComplicationsDP3DK094292 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROSIUS, FRANK C, BURANT, CHARLES F · 2011 to 2011
$5.5M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
The Impact of the Metabolic Syndrome on NeuropathyK23NS079417 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CALLAGHAN, BRIAN CHRISTOPHER · 2013 to 2017
$939k
NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG028050NIDDK NIH HHS DP3 DK094292NIDDK NIH HHS P30 DK020572NINDS NIH HHS K23 NS079417NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

objectivePrevious studies demonstrate that the metabolic syndrome is associated with distal symmetric polyneuropathy (DSP). We aimed to determine the magnitude of this effect and the precise components involved. RESEARCH DESIGN AND

methodsWe determined the symptomatic DSP prevalence in the Health, Aging, and Body Composition (Health ABC) study (prospective cohort study, with subjects aged 70-79 years at baseline), stratified by glycemic status (glucose tolerance test) and the number of additional metabolic syndrome components (updated National Cholesterol Education Program/Adult Treatment Panel III definition). DSP was defined as neuropathic symptoms (questionnaire) plus at least one of three confirmatory tests (heavy monofilament, peroneal conduction velocity, and vibration threshold). Multivariable logistic and linear regression evaluated the association of metabolic syndrome components with DSP in cross-sectional and longitudinal analyses.

resultsOf 2,382 participants with neuropathy measures (mean age 73.5 ± 2.9 years, 38.2% black, 51.7% women), 21.0% had diabetes, 29.9% prediabetes, 52.8% metabolic syndrome, and 11.1% DSP. Stratified by glycemic status, DSP prevalence increased as the number of metabolic syndrome components increased (P = 0.03). Diabetes (cross-sectional model, odds ratio [OR] 1.65 [95% CI 1.18-2.31]) and baseline hemoglobin A1C (longitudinal model, OR 1.42 [95% CI 1.15-1.75]) were the only metabolic syndrome measures significantly associated with DSP. Waist circumference and HDL were significantly associated with multiple secondary neuropathy outcomes.

conclusionsIndependent of glycemic status, symptomatic DSP is more common in those with additional metabolic syndrome components. However, the issue of which metabolic syndrome components drive this association, in addition to hyperglycemia, remains unclear. Larger waist circumference and low HDL may be associated with DSP, but larger studies with more precise metabolic measures are needed.

Indexed as

AgedAgingBlood GlucoseCross-Sectional StudiesFemaleHumansHyperglycemiaMaleMetabolic SyndromePolyneuropathiesPrevalenceWaist CircumferenceBlood Glucose

Identifiers

PMID26965720
PMCPMC4839175
OpenAlexW2330360172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.