ArticleRegenerative medicine2016
Human adipose-derived stem cells promote vascularization of collagen-based scaffolds transplanted into nude mice.
Article in Regenerative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Bilayer Scaffolds for Interface Tissue Engineering and Regenerative Medicine: A Systematic Reviews.Advances in experimental medicine and biology · 2021Pooled it
- Nanostructured Scaffold, Combined with Human Dental Pulp Stem Cell Secretome, Induces Vascularization in Medicinal Leech Model.Micromachines · 2025Article
- Progress in the Application of Multifunctional Composite Hydrogels in Promoting Tissue Repair.ACS omega · 2024Review
- Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages.Journal of biomedical science · 2024Article
- Human Dental Pulp Mesenchymal Stem Cell-Derived Soluble Factors Combined with a Nanostructured Scaffold Support the Generation of a Vascular Network In Vivo.Nanomaterials (Basel, Switzerland) · 2023Article
- Review
- Adipose mesenchymal stem cell-derived soluble factors, produced under hypoxic condition, efficiently support in vivo angiogenesis.Cell death discovery · 2023Article
- Human Adipose-Derived Stem Cell-Conditioned Medium Promotes Vascularization of Nanostructured Scaffold Transplanted into Nude Mice.Nanomaterials (Basel, Switzerland) · 2022Article
- Bladder Acellular Matrix Prepared by a Self-Designed Perfusion System and Adipose-Derived Stem Cells to Promote Bladder Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice.Stem cells translational medicine · 2020Article
- Effect of Nanostructured Scaffold on Human Adipose-Derived Stem Cells: Outcome ofNanomaterials (Basel, Switzerland) · 2020Article
- Adipose-Derived Stromal Cells Seeded on IntegraBioengineering (Basel, Switzerland) · 2020Article
- Tissue scaffolds functionalized with therapeutic elastin-like biopolymer particles.Biotechnology and bioengineering · 2020Article
- The Role of Adipose-Derived Stem Cells, Dermal Regenerative Templates, and Platelet-Rich Plasma in Tissue Engineering-Based Treatments of Chronic Skin Wounds.Stem cells international · 2020Review
- Hybrid nanocomposite as a chest wall graft with improved integration by adipose-derived stem cells.Scientific reports · 2019Article
- Sufficient therapeutic effect of cryopreserved frozen adipose-derived regenerative cells on burn wounds.Regenerative therapy · 2019Article
- Collagen-Based Tissue Engineering Strategies for Vascular Medicine.Frontiers in bioengineering and biotechnology · 2019Review
- Adipose-derived mesenchymal stem cells accelerate diabetic wound healing in a similar fashion as bone marrow-derived cells.American journal of physiology. Cell physiology · 2018Article
- Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations.Frontiers in pharmacology · 2018Review
- Effects of Metal Micro and Nano-Particles on hASCs: An In Vitro Model.Nanomaterials (Basel, Switzerland) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAfter in vivo implantation of cell-loaded devices, only the cells close to the capillaries can obtain nutrients to maintain their functions. It is known that factors secreted by stem cells, rather than stem cells themselves, are fundamental to guarantee new vascularization in the area of implant. MATERIALS &
methodsTo investigate this possibility, we have grafted mice with Bilayer and Flowable Integra(®) scaffolds, loaded or not with human adipose-derived stem cells.
resultsOur results support the therapeutic potential of human adipose-derived stem cells to induce new vascular networks of engineered organs and tissues.
conclusionThis finding suggests that our approach can help to form new vascular networks that allow sufficient vascularization of engineered organs and tissues in cases of difficult wound healing due to ischemic conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.