Evidence map›Paper›PMID 26965465›Full record

ArticleAJNR. American journal of neuroradiology2016

Evaluating Permeability Surface-Area Product as a Measure of Blood-Brain Barrier Permeability in a Murine Model.

E K Weidman, C P Foley, O Kallas, J P Dyke, A Gupta, A E Giambrone, J Ivanidze, H Baradaran, D J Ballon, P C Sanelli

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Evaluation of chronic lead effects in the blood brain barrier system by DCE-CT.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2020
    Article
  3. Image-guided mathematical modeling for pharmacological evaluation of nanomaterials and monoclonal antibodies.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020
    Review
  4. AJNR. American journal of neuroradiology · 2019
    Article
  5. Article
  6. Therapeutic Remodeling of the Tumor Microenvironment Enhances Nanoparticle Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

E K WeidmanFrom the Department of Radiology (E.K.W., C.P.F., O.K., J.P.D., A.G., J.I., H.B., D.J.B., P.C.S.), New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York.ORCID 0000-0002-3645-7964
C P FoleyFrom the Department of Radiology (E.K.W., C.P.F., O.K., J.P.D., A.G., J.I., H.B., D.J.B., P.C.S.), New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York.ORCID 0000-0001-8368-5671
O KallasFrom the Department of Radiology (E.K.W., C.P.F., O.K., J.P.D., A.G., J.I., H.B., D.J.B., P.C.S.), New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York.ORCID 0000-0002-2622-7479
J P DykeFrom the Department of Radiology (E.K.W., C.P.F., O.K., J.P.D., A.G., J.I., H.B., D.J.B., P.C.S.), New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York.ORCID 0000-0001-7170-488X
A GuptaFrom the Department of Radiology (E.K.W., C.P.F., O.K., J.P.D., A.G., J.I., H.B., D.J.B., P.C.S.), New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York.ORCID 0000-0003-2816-0340
A E GiambroneDivision of Biostatistics and Epidemiology Department of Healthcare Policy and Research (A.E.G.), Weill Cornell Medical College, New York, New York.ORCID 0000-0003-4498-8471
J IvanidzeFrom the Department of Radiology (E.K.W., C.P.F., O.K., J.P.D., A.G., J.I., H.B., D.J.B., P.C.S.), New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York.ORCID 0000-0002-6470-5400
H BaradaranFrom the Department of Radiology (E.K.W., C.P.F., O.K., J.P.D., A.G., J.I., H.B., D.J.B., P.C.S.), New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York.ORCID 0000-0002-6251-5769
D J BallonFrom the Department of Radiology (E.K.W., C.P.F., O.K., J.P.D., A.G., J.I., H.B., D.J.B., P.C.S.), New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York.ORCID 0000-0002-7162-9020
P C SanelliFrom the Department of Radiology (E.K.W., C.P.F., O.K., J.P.D., A.G., J.I., H.B., D.J.B., P.C.S.), New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York Department of Radiology (P.C.S.), Northwell Health, Manhasset, New York. psanelli@nshs.edu.ORCID 0000-0002-9633-3699
New York Hospital Queens · USCornell University · USNewYork–Presbyterian Hospital · USPresbyterian Hospital · USNorthwell Health · US

Funding

Improving Clinical Outcomes Following Subarachnoid Hemmorhage Using CT PerfusionK23NS058387 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SANELLI, PINA CHRISTINE · 2008 to 2012
$923k
Preclinical model of intra-arterial gene therapy for late infantile neuronal ceroF32NS073397 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI FOLEY, CONOR PATRICK · 2011 to 2013
$110k
NINDS NIH HHS F32 NS073397NINDS NIH HHS K23 NS058387
6 · The paper itself

Abstract

background and purposePermeability surface-area product has been suggested as a marker for BBB permeability with potential applications in clinical care and research. However, few studies have demonstrated its correlation with actual quantitative measurements of BBB permeability. Our aim was to demonstrate the correlation of quantitative permeability surface-area product and BBB permeability in a murine model by histologic confirmation. MATERIALS AND

methodsCoronal MR imaging was performed on mice treated with mannitol (n = 6) for disruption of the BBB and controls treated with saline (n = 5). Permeability surface-area product was determined by ROI placement and was compared between saline- and mannitol-treated mice. Correlation was made with contrast-enhancement measurements and immunohistologic-stained sections of tripeptidyl peptidase-1 distribution in mice treated with mannitol and saline followed by injection of a viral vector containing the CLN2 gene, which directs production of tripeptidyl peptidase-1.

resultsSignificantly increased permeability surface-area product was seen in mannitol- compared with saline-treated mice in the whole brain (P = .008), MCA territory (P = .014), and mixed vascular territories (P = .008). These findings were compared with contrast-enhancement measurements of BBB permeability and were correlated with immunohistologic-stained sections demonstrating BBB permeability to a large vector.

conclusionsPermeability surface-area product is increased in situations with known disruptions of the BBB, as evidenced by immunologic staining of large-vector passage through the BBB and concordance with contrast-enhancement measurements in a murine model. Quantitative permeability surface-area product has potential as an imaging marker of BBB permeability.

Indexed as

AnimalsBlood-Brain BarrierCapillary PermeabilityDisease Models, AnimalMiceTripeptidyl-Peptidase 1Tripeptidyl-Peptidase 1

Identifiers

PMID26965465
PMCPMC4946982
OpenAlexW2311660052

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.