ArticleRheumatology international2016
Incidence and risk factors of fractures in patients with rheumatoid arthritis: an Asian prospective cohort study.
Article in Rheumatology international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- The prevalence of osteoporosis in rheumatoid arthritis patient: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Incidence of fractures among patients with rheumatoid arthritis: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Pooled it
- Pooled it
- Denosumab improves bone mineral density and microarchitecture in rheumatoid arthritis: randomized controlled trial by HR-pQCT.Journal of bone and mineral metabolism · 2023Trial
- Temporal progression of bone loss, trabecular microarchitectural deterioration, and mechanical impairment in a rat model of collagen-induced arthritis.Frontiers in medicine · 2026Article
- Subchondral bone strength of the metacarpal head and its related factors in patients with rheumatoid arthritis.Scientific reports · 2025Observational
- Increasing fracture incidence over 13 years in patients with rheumatoid arthritis from the IORRA cohort.Journal of bone and mineral metabolism · 2025Observational
- Association between vertebral fractures and comorbidities in patients with rheumatoid arthritis: a cross-sectional study.Journal of bone and mineral metabolism · 2025Article
- Treatment Goals for Prevention of Vertebral Fractures in Patients with Rheumatoid Arthritis.Journal of bone metabolism · 2025Article
- Article
- Osteoporosis-related fractures in men and women with established and early rheumatoid arthritis: predictors and risk compared with the general population.BMC rheumatology · 2023Article
- Article
- Effect of sarcopenia and poor balance on vertebral spinal osteoporotic fracture in female rheumatoid arthritis.Scientific reports · 2022Article
- Incidence and predictors of fragility fracture in postmenopausal rheumatoid arthritis patients receiving oral bisphosphonates: a longitudinal observational study.BMC rheumatology · 2022Article
- Impact of Treat-to-Target Therapy on Bone Mineral Density Loss in Patients With Rheumatoid Arthritis: A Prospective Cohort Study.Frontiers in endocrinology · 2022Article
- Fracture Risk and Its Prevention Patterns in Korean Patients with Polymyalgia Rheumatica: a Retrospective Cohort Study.Journal of Korean medical science · 2021Article
- Risk of Non-Vertebral Fracture in Gout Compared to Rheumatoid Arthritis.Journal of clinical medicine · 2021Article
- Comparative Risk of Nonvertebral Fractures Among Patients With Rheumatoid Arthritis Treated With Biologic or Targeted Synthetic Disease-Modifying Antirheumatic Drugs.ACR open rheumatology · 2021Article
- [Perioperative management in the treatment of trauma for rheumatics under immunosuppression].Der Unfallchirurg · 2020Review
- A paradigm shift in studies based on rheumatoid arthritis clinical registries.The Korean journal of internal medicine · 2019Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) patients have high risk for osteoporosis and fracture. We aimed to identify the incidence rate and risk factors of fractures in Asian RA patients. A total of 3557 RA patients in the KORean Observational study Network for Arthritis (KORONA) were included and observed over a mean follow-up of 18 months. A fracture was assessed as total, major, or minor fractures; major fracture was defined as a vertebral or hip fracture, and the other fractures were classified as minor fractures. The standardized incidence ratio (SIR) of fracture in RA patients was calculated compared with general population, and possible risk factors for fractures were explored using multivariable logistic regression analyses. A total of 194 patients with 215 fractures were observed, and the SIR of the total fracture in RA patients was 2.2 [95 % confidence interval (CI) 1.9-2.6]. The SIRs of major and minor fractures were 1.5 (CI 1.1-2.0) and 3.0 (CI 2.5-3.7), respectively. Advanced age [odds ratio (OR) 1.03, CI 1.02-1.05, p < 0.01] and having history of prior fracture (OR 2.17, CI 1.54-3.08, p < 0.01) were risk factors for total fractures. In addition, higher HAQ increased fracture risk (OR 2.02, CI 1.05-3.89, p = 0.04), whereas the use of bisphosphonate showed protective effect for future fractures (OR 0.34, CI 0.14-0.87, p = 0.02) in patients with osteoporosis. RA patients had a 2.2-fold increased risk of fractures as compared with general population. In Asian RA patients, advanced age and history of prior fracture were the most important risk factors for new fractures.
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