ArticleScientific reports2016
Unique glycosignature for intervertebral disc and articular cartilage cells and tissues in immaturity and maturity.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Alterations of bovine nucleus pulposus cells with aging.Aging cell · 2023Article
- An insight on theFASEB bioAdvances · 2023Article
- Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties.Signal transduction and targeted therapy · 2021Review
- The synovial surface of the articular cartilage.European journal of histochemistry : EJH · 2020Article
- Critical aspects and challenges for intervertebral disc repair and regeneration-Harnessing advances in tissue engineering.JOR spine · 2018Review
- Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury.Science advances · 2018Article
- A method for characterising human intervertebral disc glycosaminoglycan disaccharides using liquid chromatography-mass spectrometry with multiple reaction monitoring.European cells & materials · 2018Article
- Lectins selectively label cartilage condensations and the otic neuroepithelium within the embryonic chicken head.Journal of anatomy · 2017Article
- Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc.Signal transduction and targeted therapyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, on/off markers for intervertebral disc (IVD) and articular cartilage (AC) cells (chondrocytes) and distinct glycoprofiles of cell and tissue-types were identified from immaturity to maturity. Three and eleven month-old ovine IVD and AC tissues were histochemically profiled with a panel of lectins and antibodies. Relationships between tissue and cell types were analysed by hierarchical clustering. Chondroitin sulfate (CS) composition of annulus fibrosus (AF), nucleus pulposus (NP) and AC tissues was determined by HPLC analysis. Clear on/off cell type markers were identified, which enabled the discrimination of chondrocytes, AF and NP cells. AF and NP cells were distinguishable using MAA, SNA-I, SBA and WFA lectins, which bound to both NP cells and chondrocytes but not AF cells. Chondrocytes were distinguished from NP and AF cells with a specific binding of LTA and PNA lectins to chondrocytes. Each tissue showed a unique CS composition with a distinct switch in sulfation pattern in AF and NP tissues upon disc maturity while cartilage maintained the same sulfation pattern over time. In conclusion, distinct glycoprofiles for cell and tissue-types across age groups were identified in addition to altered CS composition and sulfation patterns for tissue types upon maturity.
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