Evidence map›Paper›PMID 26965173›Full record

ArticlePediatric rheumatology online journal2016

Familial autoimmunity in the Childhood Arthritis and Rheumatology Research Alliance registry.

Sampath Prahalad, Courtney E McCracken, Lori A Ponder, Sheila T Angeles-Han, Kelly A Rouster Stevens, Larry B Vogler, Carl D Langefeld, Susan D Thompson, Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry Investigators

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric rheumatology online journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Juvenile Dermatomyositis: New Clues to Diagnosis and Therapy.Current treatment options in rheumatology · 2021
    Article
  5. Article
  6. How Should We Classify Kawasaki Disease?Frontiers in immunology · 2018
    Review
  7. The autoimmune burden in juvenile idiopathic arthritis.Italian journal of pediatrics · 2017
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sampath PrahaladDepartment of Pediatrics, Emory University School of Medicine, 1760 Haygood Dr NE, Atlanta, GA, 30322, USA. sprahal@emory.edu.
Courtney E McCrackenDepartment of Pediatrics, Emory University School of Medicine, 1760 Haygood Dr NE, Atlanta, GA, 30322, USA.
Lori A PonderChildren's Healthcare of Atlanta, Atlanta, GA, USA.
Sheila T Angeles-HanDepartment of Pediatrics, Emory University School of Medicine, 1760 Haygood Dr NE, Atlanta, GA, 30322, USA.
Kelly A Rouster StevensDepartment of Pediatrics, Emory University School of Medicine, 1760 Haygood Dr NE, Atlanta, GA, 30322, USA.
Larry B VoglerDepartment of Pediatrics, Emory University School of Medicine, 1760 Haygood Dr NE, Atlanta, GA, 30322, USA.
Carl D LangefeldCenter for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Susan D ThompsonCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry Investigators
Emory University · USCincinnati Children's Hospital Medical Center · US

Funding

Pediatric Rheumatology Tissue RepostoryP01AR048929 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI THOMPSON, SUSAN D · 2003 to 2015
$13.6M
ROLE OF ANGPTL4, AN ANGIOGENIC MEDIATOR, IN ARTHRITISP30AR047363 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI FLICK, MATTHEW J. · 2001 to 2015
$9.2M
Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7M
CARRA: Accelerating Toward an Evidence Based Culture in Pediatric RheumatologyRC2AR058934 · NIAMS · DUKE UNIVERSITY · PI ILOWITE, NORMAN T, SANDBORG, CHRISTY IRENE · 2009 to 2010
$6.8M
Segmental chromosome sharing in affected relatives with Juvenile ArthritisR01AR060893 · NIAMS · EMORY UNIVERSITY · PI PRAHALAD, SAMPATH · 2011 to 2014
$1.5M
NIAMS NIH HHS 01-AR060893NIAMS NIH HHS P01 AR048929NIAMS NIH HHS P01-AR048929NIAMS NIH HHS P30-AR0470363NIAMS NIH HHS P30 AR047363NIAMS NIH HHS P30 AR070549NIAMS NIH HHS R01 AR060893NIAMS NIH HHS RC2 AR058934NIAMS NIH HHS RC2-AR058934
6 · The paper itself

Abstract

backgroundClinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and juvenile dermatomyositis (JDM) in the CARRA Registry, the largest multicenter observational Registry for pediatric rheumatic disease.

methodsChildren with JIA, cSLE and JDM enrolled in the CARRA Registry between May 2010 and May 2012 were investigated for differences in proportion of subjects who had first-degree relatives (FDR) with autoimmunity. If a significant difference was detected, pairwise comparisons, adjusted for multiple comparisons, were made.

resultsThere were 4677 JIA, 639 cSLE and 440 JDM subjects. The proportion of subjects having FDR with any autoimmune disease in the JDM group (20.5 %) was less compared to subjects with JIA (31.8 %, p < 0.001) or SLE (31.9 %; p < 0.001). Significantly greater proportion of JIA cases had FDR with inflammatory arthritis (13 %) compared to cSLE (9.2 %, p = 0.007) or JDM (4.3 %, p <0.001). Significantly greater proportion of cSLE cases had FDR with SLE (11.1 % vs. 1.7 % for JIA and 1.1 % for JDM p < 0.001) or type-I diabetes (7.4 % for cSLE vs. 3.1 % for JIA and 3.0 % for JDM p < 0.001).

conclusionHigher proportions of subjects with JIA and cSLE have FDR with autoimmunity compared to those of JDM. Relatives of cSLE cases had an increased prevalence of SLE, and relatives of JIA cases were enriched for inflammatory arthropathies demonstrating distinct patterns of familial autoimmunity among these phenotypes.

Indexed as

AutoimmunityBiomedical ResearchRegistriesArthritis, JuvenileChildChild, PreschoolFemaleHumansMalePrevalenceRetrospective StudiesRheumatologyUnited States

Identifiers

PMID26965173
PMCPMC4785640
OpenAlexW2295476730

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.