Evidence map›Paper›PMID 26965149›Full record

ReviewClinical and experimental nephrology2017

The role of the gastrointestinal tract and microbiota on uremic toxins and chronic kidney disease development.

David Briskey, Patrick Tucker, David W Johnson, Jeff S Coombes

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical and experimental nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

David BriskeySchool of Human Movement and Nutrition Sciences, University of Queensland, St Lucia, QLD, Australia. d.briskey@uq.edu.au.ORCID http://orcid.org/0000-0001-9867-6700
Patrick TuckerClinical Biochemistry Laboratory, Central Queensland University, Rockhampton, Australia.
David W JohnsonCentre for Kidney Disease Research, School of Medicine, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia.
Jeff S CoombesSchool of Human Movement and Nutrition Sciences, University of Queensland, St Lucia, QLD, Australia.
The University of Queensland · AUCentral Queensland University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is well-established that uremic toxins are positively correlated with the risk of developing chronic kidney disease and cardiovascular disease. In addition, emerging data suggest that gut bacteria exert an influence over both the production of uremic toxins and the development of chronic kidney disease. As such, modifying the gut microbiota may have the potential as a treatment for chronic kidney disease. This is supported by data that suggest that rescuing microbiota dysbiosis may: reduce uremic toxin production; prevent toxins and pathogens from crossing the intestinal barrier; and, reduce gastrointestinal tract transit time allowing nutrients to reach the microbiota in the distal portion of the gastrointestinal tract. Despite emerging literature, the gut-kidney axis has yet to be fully explored. A special focus should be placed on examining clinically translatable strategies that might encourage improvements to the microbiome, thereby potentially reducing the risk of the development of chronic kidney disease. This review aims to present an overview of literature linking changes to the gastrointestinal tract with microbiota dysbiosis and the development and progression of chronic kidney disease.

Indexed as

Gastrointestinal MicrobiomeAnimalsBacteriaBacterial TranslocationDisease ProgressionDysbiosisGastrointestinal TractHost-Pathogen InteractionsHumansProbioticsRenal Insufficiency, ChronicUremiaGastrointestinal tractKidney diseaseMicrobiotaPermeabilityProbiotics

Identifiers

PMID26965149
OpenAlexW2295899534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.