ArticleBiogerontology2016
Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians.
Article in Biogerontology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Cancer progression through the lens of age-induced metabolic reprogramming.Nature reviews. Cancer · 2025Review
- Beyond hallmarks of aging - biological age and emergence of aging networks.Aging pathobiology and therapeutics · 2025Article
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- COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.Nature metabolism · 2022Article
- Functional Role of Mitochondrial DNA in Cancer Progression.International journal of molecular sciences · 2022Review
- Frailty and Biological Age.Annals of geriatric medicine and research · 2021Article
- Feature Selection Algorithms Enhance the Accuracy of Frailty Indexes as Measures of Biological Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Article
- Examination of the Dimensions of Biological Age.Frontiers in genetics · 2019Review
- Adaptation to metabolic dysfunction during aging: Making the best of a bad situation.Experimental gerontology · 2018Review
- The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based Study.Nutrients · 2017Article
- The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age.GeroScience · 2017Article
- Metabolic and Genetic Markers of Biological Age.Frontiers in genetics · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Energy expenditure decreases with age, but in the oldest-old, energy demand for maintenance of body functions increases with declining health. Uncoupling proteins have profound impact on mitochondrial metabolic processes; therefore, we focused attention on mitochondrial uncoupling protein genes. Alongside resting metabolic rate (RMR), two SNPs in the promoter region of UCP2 were associated with healthy aging. These SNPs mark potential binding sites for several transcription factors; thus, they may affect expression of the gene. A third SNP in the 3'-UTR of UCP3 interacted with RMR. This UCP3 SNP is known to impact UCP3 expression in tissue culture cells, and it has been associated with body weight and mitochondrial energy metabolism. The significant main effects of the UCP2 SNPs and the interaction effect of the UCP3 SNP were also observed after controlling for fat-free mass (FFM) and physical-activity related energy consumption. The association of UCP2/3 with healthy aging was not found in males. Thus, our study provides evidence that the genetic risk factors for healthy aging differ in males and females, as expected from the differences in the phenotypes associated with healthy aging between the two sexes. It also has implications for how mitochondrial function changes during aging.
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Registered trials
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