ArticleBMC cancer2016
Cerebral infarction in advanced non-small cell lung cancer: a case control study.
Article in BMC cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Peripheral blood monocytes could be associated with brain metastasis and affect patient prognosis in breast cancer: a retrospective study.Frontiers in oncology · 2026Article
- Comparison of the prognosis of symptomatic cerebral infarction and pulmonary embolism in patients with advanced non-small cell lung cancer.Cancer medicine · 2023Article
- Complications and risk factors after digital subtraction angiography: 1-year single-center study.Journal of cerebrovascular and endovascular neurosurgery · 2022Article
- Cancer-related stroke: Exploring personalized therapy strategies.Brain and behavior · 2022Review
- In Patients with Acute Ischemic Stroke and Cancer: The Shorter Interval, the Higher D-Dimer.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Computed tomography-guided microwave ablation for non-small cell lung cancer patients on antithrombotic therapy: a retrospective cohort study.Quantitative imaging in medicine and surgery · 2022Article
- Clinical impact of cerebral infarction in patients with non-small cell lung cancer.International journal of clinical oncology · 2022Article
- Comorbidity Patterns of Older Lung Cancer Patients in Northeast China: An Association Rules Analysis Based on Electronic Medical Records.International journal of environmental research and public health · 2020Article
- Importance of Standard Treatment in Prognosis of Patients with Ovarian Cancer and Associated Cerebral Infarction.Clinical interventions in aging · 2020Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvanced non-small cell lung cancer (NSCLC) patients often develop thromboembolic events, including cerebral infarction (CI). However, the relationship between advanced NSCLC and CI has not been thoroughly investigated. We examined the association between advanced NSCLC and CI and risk factors for CI in advanced or post-operative recurrent NSCLC patients.
methodsWe retrospectively investigated 515 patients diagnosed with advanced or post-operative recurrent NSCLC at Juntendo University Hospital between April 2009 and March 2014.
resultsAmong the 515 patients evaluated, 15 patients (2.9%) developed CI after diagnosis of advanced or post-operative recurrent NSCLC. Univariate and multivariate analyses were conducted, and brain metastasis was the only significant independent risk factor for CI (odds ratio 5.24, 95% confidence interval 1.72-16.10, p = 0.004). The incidence was 6.3% in these patients. The median survival time was 36 days, and 1-year survival rate was 6.7% after development of CI. Overall survival from diagnosis of advanced NSCLC or post-operative recurrence was significantly shorter in patients with CI than in patients without CI (223 days versus 895 days; HR, 3.46; 95% confidence interval, 2.04-6.02; p = 0.001).
conclusionsThe incidence of CI is high in advanced or post-operative recurrent NSCLC, and is especially higher in patients with brain metastasis than in those without brain metastasis. Moreover, CI may affect patient's prognosis. Careful monitoring for the development of CI in patients with advanced or post-operative recurrent NSCLC is needed, especially for patients with brain metastasis.
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