Evidence map›Paper›PMID 26964844›Full record

ReviewClinical journal of the American Society of Nephrology : CJASN2016

Urinary Stone Disease: Advancing Knowledge, Patient Care, and Population Health.

Charles D Scales, Gregory E Tasian, Andrew L Schwaderer, David S Goldfarb, Robert A Star, Ziya Kirkali

Open access · bronzeAbstract readReview
In one paragraph

Review in Clinical journal of the American Society of Nephrology : CJASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 2 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 2 syntheses or guidelines pooled it, 181 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Role of FGF23 in Pediatric Hypercalciuria.BioMed research international · 2017
    Trial
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Risk Factors for Upper Urinary Tract Stone Recurrence: A Retrospective Study of 247 Patients.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Charles D ScalesDuke Clinical Research Institute and Division of Urologic Surgery, Duke University School of Medicine, Durham, North Carolina.
Gregory E TasianChildren's Hospital of Philadelphia and Department of Urology, University of Pennsylvania, Philadelphia, Pennsylvania.
Andrew L SchwadererDepartment of Pediatrics, Section of Nephrology, Nationwide Children's Hospital, Columbus, Ohio.
David S GoldfarbDivision of Nephrology, New York University School of Medicine, New York, New York; and.
Robert A StarDivision of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
Ziya KirkaliDivision of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
National Institute of Diabetes and Digestive and Kidney Diseases · USChildren's Hospital of Philadelphia · USClinical Research Institute · USNationwide Children's Hospital · USNew York University · US

Funding

Primary HyperoxaluriaU54DK083908 · NIDDK · MAYO CLINIC ROCHESTER · PI MILLINER, DAWN SCHMAUTZ · 2009 to 2018
$12.3M
The interface between critical acid-base mediators and the renal bacterial defenseR01DK106286 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI HAINS, DAVID SULLIVAN, SCHWADERER, ANDREW LAWRENCE · 2015 to 2018
$1.6M
Identifying and Mitigating Risk Factors for Dehydration-Mediated Nephrolithiasis in AdolescentsK23DK106428 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI TASIAN, GREGORY EDWARD · 2015 to 2019
$836k
Urinary Dysfunction in the Elderly: Informing Accountable Urologic CareR03AG048130 · NIA · DUKE UNIVERSITY · PI SCALES, CHARLES D · 2014 to 2015
$232k
NIA NIH HHS R03 AG048130NIDDK NIH HHS K23 DK106428NIDDK NIH HHS R01 DK106286NIDDK NIH HHS U54 DK083908
6 · The paper itself

Abstract

Expanding epidemiologic and physiologic data suggest that urinary stone disease is best conceptualized as a chronic metabolic condition punctuated by symptomatic, preventable stone events. These acute events herald substantial future chronic morbidity, including decreased bone mineral density, cardiovascular disease, and CKD. Urinary stone disease imposes a large and growing public health burden. In the United States, 1 in 11 individuals will experience a urinary stone in their lifetime. Given this high incidence and prevalence, urinary stone disease is one of the most expensive urologic conditions, with health care charges exceeding $10 billion annually. Patient care focuses on management of symptomatic stones rather than prevention; after three decades of innovation, procedural interventions are almost exclusively minimally invasive or noninvasive, and mortality is rare. Despite these advances, the prevalence of stone disease has nearly doubled over the past 15 years, likely secondary to dietary and health trends. The NIDDK recently convened a symposium to assess knowledge and treatment gaps to inform future urinary stone disease research. Reducing the public health burden of urinary stone disease will require key advances in understanding environmental, genetic, and other individual disease determinants; improving secondary prevention; and optimal population health strategies in an increasingly cost-conscious care environment.

Indexed as

Population HealthDietEnvironmental ExposureHumansPrevalencePrimary PreventionSecondary PreventionUrinary CalculiCardiovascular DiseasesDisease ManagementHealth ExpendituresHumanskidney stonesMorbidityNational Institute of Diabetes and Digestive and Kidney Diseases (U.S.)Patient CarePublic HealthSecondary Prevention

Identifiers

PMID26964844
PMCPMC4934851
OpenAlexW2295718378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.