ArticleVeterinary immunology and immunopathology2016
Natural resistance to experimental feline infectious peritonitis virus infection is decreased rather than increased by positive genetic selection.
Article in Veterinary immunology and immunopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Serological response to feline coronavirus in the UK domestic cat population.The Journal of general virology · 2026Article
- Development and Validation of a Triplex RT-qPCR Assay for Rapid Clinical Diagnosis and Serotyping of Feline Infectious Peritonitis Virus.International journal of molecular sciences · 2026Article
- Review
- Patterns of Feline Coronavirus Shedding and Associated Factors in Cats from Breeding Catteries.Viruses · 2023Article
- Feline breeding and pregnancy management: What is normal and when to intervene.Journal of feline medicine and surgery · 2022Review
- The Population Diversity of Candidate Genes for Resistance/Susceptibility to Coronavirus Infection in Domestic Cats: An Inter-Breed Comparison.Pathogens (Basel, Switzerland) · 2021Article
- Prevalence of Feline Coronavirus Shedding in German Catteries and Associated Risk Factors.Viruses · 2020Article
- Evaluation of Interferon-Gamma Polymorphisms as a Risk Factor in Feline Infectious Peritonitis Development in Non-Pedigree Cats-A Large Cohort Study.Pathogens (Basel, Switzerland) · 2020Article
- The Effect of Natural Feline Coronavirus Infection on the Host Immune Response: A Whole-Transcriptome Analysis of the Mesenteric Lymph Nodes in Cats with and without Feline Infectious Peritonitis.Pathogens (Basel, Switzerland) · 2020Article
- Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis.Journal of feline medicine and surgery · 2018Article
- Diagnosis of feline infectious peritonitis: Update on evidence supporting available tests.Journal of feline medicine and surgery · 2018Review
- Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor.PLoS pathogens · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A previous study demonstrated the existence of a natural resistance to feline infectious peritonitis virus (FIPV) among 36% of randomly bred laboratory cats. A genome wide association study (GWAS) on this population suggested that resistance was polygenic but failed to identify any strong specific associations. In order to enhance the power of GWAS or whole genome sequencing to identify strong genetic associations, a decision was made to positively select for resistance over three generations. The inbreeding experiment began with a genetically related parental (P) population consisting of three toms and four queens identified from among the survivors of the earlier study and belonging to a closely related subgroup (B). The subsequent effects of inbreeding were measured using 42 genome-wide STR markers. P generation cats produced 57 first filial (F1) kittens, only five of which (9.0%) demonstrated a natural resistance to FIPV infection. One of these five F1 survivors was then used to produce six F1/P-backcrosses kittens, only one of which proved resistant to FIP. Six of eight of the F1 and F1/P survivors succumbed to a secondary exposure 4-12 months later. Therefore, survival after both primary and secondary infection was decreased rather than increased by positive selection for resistance. The common genetic factor associated with this diminished resistance was a loss of heterozygosity.
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