ArticleJournal of biomechanical engineering2016
Reduced Biaxial Contractility in the Descending Thoracic Aorta of Fibulin-5 Deficient Mice.
Article in Journal of biomechanical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- Biomechanical function of the murine cervix with elastic fiber deficiency.Journal of the mechanical behavior of biomedical materials · 2026Article
- Endothelial cell (EC)-specific Ctgf/Ccn2 expression increases EC reprogramming and atherosclerosis.Matrix biology : journal of the International Society for Matrix Biology · 2025Article
- A Systematic Comparison of Normal Structure and Function of the Greater Thoracic Vessels.Annals of biomedical engineering · 2024Article
- Smooth muscle contribution to vaginal viscoelastic response.Journal of the mechanical behavior of biomedical materials · 2023Article
- Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice.Journal of biomechanical engineering · 2022Article
- Biaxial Murine Vaginal Remodeling With Reproductive Aging.Journal of biomechanical engineering · 2022Article
- The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections.European journal of clinical investigation · 2022Review
- Reduced Smooth Muscle Contractile Capacity Facilitates Maladaptive Arterial Remodeling.Journal of biomechanical engineering · 2022Article
- Biomechanical Properties of Mouse Carotid Arteries With Diet-Induced Metabolic Syndrome and Aging.Frontiers in bioengineering and biotechnology · 2022Article
- Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function.Scientific reports · 2021Article
- The Role of Biaxial Loading on Smooth Muscle Contractility in the Nulliparous Murine Cervix.Annals of biomedical engineering · 2021Article
- Developmental origins of mechanical homeostasis in the aorta.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Differential biomechanical responses of elastic and muscular arteries to angiotensin II-induced hypertension.Journal of biomechanics · 2021Article
- Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data.Frontiers in physiology · 2021Article
- [Experimental measurement and modeling analysis of active and passive mechanical properties of arterial vessel wall].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Mechanics-driven mechanobiological mechanisms of arterial tortuosity.Science advances · 2020Article
- Numerical knockouts-In silico assessment of factors predisposing to thoracic aortic aneurysms.PLoS computational biology · 2020Article
- Disturbed nitric oxide signalling gives rise to congenital bicuspid aortic valve and aortopathy.Disease models & mechanisms · 2020Article
- Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson-Gilford progeria syndrome.Journal of the Royal Society, Interface · 2020Article
- Elastic fibers and biomechanics of the aorta: Insights from mouse studies.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
The precise role of smooth muscle cell contractility in elastic arteries remains unclear, but accumulating evidence suggests that smooth muscle dysfunction plays an important role in the development of thoracic aortic aneurysms and dissections (TAADs). Given the increasing availability of mouse models of these conditions, there is a special opportunity to study roles of contractility ex vivo in intact vessels subjected to different mechanical loads. In parallel, of course, there is a similar need to study smooth muscle contractility in models that do not predispose to TAADs, particularly in cases where disease might be expected. Multiple mouse models having compromised glycoproteins that normally associate with elastin to form medial elastic fibers present with TAADs, yet those with fibulin-5 deficiency do not. In this paper, we show that deletion of the fibulin-5 gene results in a significantly diminished contractility of the thoracic aorta in response to potassium loading despite otherwise preserved characteristic active behaviors, including axial force generation and rates of contraction and relaxation. Interestingly, this diminished response manifests around an altered passive state that is defined primarily by a reduced in vivo axial stretch. Given this significant coupling between passive and active properties, a lack of significant changes in passive material stiffness may help to offset the diminished contractility and thereby protect the wall from detrimental mechanosensing and its sequelae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.