ArticleMedicine2016
Prolong Exposure of NSAID in Patients With RA Will Decrease the Risk of Dementia: A Nationwide Population-Based Cohort Study.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
- Prevalence of cognitive impairment in patients with rheumatoid arthritis: a cross sectional study.BMC psychiatry · 2022Article
- No increased risk of Alzheimer's disease among people with immune-mediated inflammatory diseases: findings from a longitudinal cohort study of U.S. older adults.BMC rheumatology · 2021Article
- No association between rheumatoid arthritis and cognitive impairment in a cross-sectional national sample of older U.S. adults.BMC rheumatology · 2021Article
- Trends in incidence of dementia among patients with rheumatoid arthritis: A population-based cohort study.Seminars in arthritis and rheumatism · 2021Article
- Alzheimer's Disease: From Pathogenesis to Mesenchymal Stem Cell Therapy - Bridging the Missing Link.Frontiers in cellular neuroscience · 2021Review
- Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis.Annals of neurology · 2020Article
- Prevalence of affective disorders and dementia in inflammatory polyarthropathies.European archives of psychiatry and clinical neuroscience · 2020Article
- Can Disease-Modifying Anti-Rheumatic Drugs Reduce the Risk of Developing Dementia in Patients with Rheumatoid Arthritis?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Article
- Ankylosing Spondylitis Is Associated With Risk of New-Onset Obstructive Sleep Apnea: A Nationwide Population-Based Cohort Study.Frontiers in medicine · 2019Article
- Association of iron deficiency anemia with tuberculosis in Taiwan: A nationwide population-based study.PloS one · 2019Article
- NSAID Exposure and Risk of Alzheimer's Disease: An Updated Meta-Analysis From Cohort Studies.Frontiers in aging neuroscience · 2018Article
- Physical activity, body functions and disability among middle-aged and older Spanish adults.BMC geriatrics · 2017Article
- Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis.Scientific reports · 2017Article
- Probiotic bacteria: a viable adjuvant therapy for relieving symptoms of rheumatoid arthritis.Inflammopharmacology · 2016Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA), a chronic, systemic inflammatory disorder, primarily affects joints. Several studies have indicated that early inflammation, cardiovascular disease, and depression in patients were associated with a considerably increased risk of dementia. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for treating RA. NSAIDs facilitate alleviating RA-associated chronic pain, inflammation, and swelling. Therefore, we conducted this nationwide study for evaluating the association between the dementia risk and NSAID treatment in patients with RA.The RA cohort comprised patients aged 20 years and older who were newly diagnosed with RA between 2000 and 2011, with data obtained from the Registry of Catastrophic Illnesses Patient Database (RCIPD). Patients without RA were frequency matched with the RA cohort at a 1:4 ratio according to age, sex, and year of RA diagnosis. The relative risks of dementia were estimated using Cox proportional hazard models.The risk of dementia in the RA cohort was not significantly higher than that in the non-RA cohort (adjusted HR [hazard ratio] = 0.95, 95% confidence interval [CI] = 0.87-1.02). Regarding the duration of NSAID treatment, the risk of dementia was significantly lower when the RA cohort used NSAIDs for >2191 days (HR = 0.56, 95% CI = 0.45-0.68).A longer duration of NSAID treatment possibly reduces the risk of dementia. Additional studies are warranted for verifying the association of dementia risk with NSAID treatment in patients with RA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.