ArticleMedicine2016
A Matched Influenza Vaccine Strain Was Effective in Reducing the Risk of Acute Myocardial Infarction in Elderly Persons: A Population-Based Study.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Influenza vaccination and the risk of myocardial infarction: a meta-epidemiology study.BMC public health · 2026Pooled it
- Impact of influenza, herpes zoster, and pneumococcal vaccinations on the incidence of cardiovascular events in subjects aged over 65 years: a systematic review.GeroScience · 2023Pooled it
- Protective effect of influenza vaccination on cardiovascular diseases: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Effects of Respiratory Vaccines in Older Adults with Cardiovascular Diseases: A Scoping Review.Vaccines · 2026Review
- The burden of influenza and the role of influenza vaccination in adults aged 50-64 years: A summary of available evidence.Human vaccines & immunotherapeutics · 2023Review
- Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death.Cardiovascular research · 2021Article
- Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality.Ageing research reviews · 2020Review
- Immune Mechanisms in Cardiovascular Diseases Associated With Viral Infection.Frontiers in immunology · 2020Review
- Laboratory-Confirmed Respiratory Infections as Predictors of Hospital Admission for Myocardial Infarction and Stroke: Time-Series Analysis of English Data for 2004-2015.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Observational
- Influenza vaccine as a coronary intervention for prevention of myocardial infarction.Heart (British Cardiac Society) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to explore whether matched or mismatched strains of influenza vaccines (IVs) are beneficial at reducing the risk of acute myocardial infarction (AMI) in elderly persons.Data were obtained from the Longitudinal Health Database 2005 (LHID 2005) which is maintained by the National Health Insurance Research Institute in Taiwan. The analytical data included individuals who were vaccinated with mismatched vaccines during the October 2007 to December 2007 season and individuals vaccinated with matched strains during the October 2008 to December 2008 season. All participants were 65 years of age and older. In this analysis, individuals were considered to be exposed if their records showed that they were vaccinated against influenza, and they were considered to be nonexposed if they were not vaccinated during these seasons. A Cox hazard model was used to estimate AMI hazard ratio.This study enrolled 93,051 exposed and 109,007 unexposed individuals. The AMI hazards ratios (HRs) for the men and women exposed to mismatched vaccine (in 2007) were 0.990 (95% confidence interval [CI], 0.745-1.316) and 1.102 (95% CI: 0.803-1.513), respectively. Men exposed to matched vaccines (in 2008) had significant HRs (HR: 0.681; 95% CI: 0.509-0.912) while the HRs in the women were barely significant (HR: 0.737; 95% CI: 0.527-1.029).AMI risk could be particularly reduced in men if the IV matches well with the circulating strains in elderly people 65 years of age and older.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.