ReviewClinical & translational immunology2016
Involvement of B cells in non-infectious uveitis.
Review in Clinical & translational immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- The Immunopathogenesis of uveitis.Frontiers in medicine · 2026Review
- Immune landscape in children with X-linked retinoschisis.BMC immunology · 2025Article
- Bilateral spontaneous retinal dialysis in multiple sclerosis related intermediate uveitis: Unusual case report.American journal of ophthalmology case reports · 2025Article
- Divergent B-cell and cytotoxic TNK cell activation signatures in HLA-B27-associated ankylosing spondylitis and acute anterior uveitis.Frontiers in immunology · 2025Article
- Primary Sjögren's syndrome complicated by renal tubular acidosis and acute bilateral uveitis: a case report and literature review.The Journal of international medical research · 2024Review
- Pathogenesis and current therapies for non-infectious uveitis.Clinical and experimental medicine · 2023Review
- The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases.Journal of neuroinflammation · 2022Review
- Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice.Protein & cell · 2022Article
- A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis - A phase I clinical trial.Frontiers in medicine · 2022Article
- Immune Cells in Subretinal Wound Healing and Fibrosis.Frontiers in cellular neuroscience · 2022Review
- Intermediate uveitis associated with MS: Diagnosis, clinical features, pathogenic mechanisms, and recommendations for management.Neurology(R) neuroimmunology & neuroinflammation · 2021Review
- A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis.Frontiers in immunology · 2021Review
- Features of ectopic lymphoid-like structures in human uveitis.Experimental eye research · 2020Article
- Whole Transcriptome Analysis Reveals Heterogeneity in B Cell Memory Populations in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis.Frontiers in immunology · 2020Article
- Resolution of uveitis.Seminars in immunopathology · 2019Review
- Re-programming immunosurveillance in persistent non-infectious ocular inflammation.Progress in retinal and eye research · 2018Review
- Comparison of Aqueous and Vitreous Lymphocyte Populations From Two Rat Models of Experimental Uveitis.Investigative ophthalmology & visual science · 2018Article
- A model to study complement involvement in experimental retinal degeneration.Upsala journal of medical sciences · 2018Article
- High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis.Frontiers in immunology · 2018Article
- Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease.Mediators of inflammation · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Non-infectious uveitis-or intraocular inflammatory disease-causes substantial visual morbidity and reduced quality of life amongst affected individuals. To date, research of pathogenic mechanisms has largely been focused on processes involving T lymphocyte and/or myeloid leukocyte populations. Involvement of B lymphocytes has received relatively little attention. In contrast, B-cell pathobiology is a major field within general immunological research, and large clinical trials have showed that treatments targeting B cells are highly effective for multiple systemic inflammatory diseases. B cells, including the terminally differentiated plasma cell that produces antibody, are found in the human eye in different forms of non-infectious uveitis; in some cases, these cells outnumber other leukocyte subsets. Recent case reports and small case series suggest that B-cell blockade may be therapeutic for patients with non-infectious uveitis. As well as secretion of antibody, B cells may promote intraocular inflammation by presentation of antigen to T cells, production of multiple inflammatory cytokines and support of T-cell survival. B cells may also perform various immunomodulatory activities within the eye. This translational review summarizes the evidence for B-cell involvement in non-infectious uveitis, and considers the potential contributions of B cells to the development and control of the disease. Manipulations of B cells and/or their products are promising new approaches to the treatment of non-infectious uveitis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.