ArticleWorld journal of hepatology2016
Burn injury induces histopathological changes and cell proliferation in liver of rats.
Article in World journal of hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Protective effects of insulin treatment in the morphological alterations and oxidative damage to DNA in the liver of young rats subjected to skin scald burn injury.International journal of burns and trauma · 2025Article
- Description of Aspartate Aminotransferase and Alanine Aminotransferase in Burn Patients at the Burn Unit of Dr. Hasan Sadikin General Hospital (Rshs) Bandung.Annals of burns and fire disasters · 2023Article
- Characteristics And Outcome Influence Of Increased Plasma Triglyceride Level In Severely Burned Adult Patients.Annals of burns and fire disasters · 2021Article
- Protective Effects of Melatonin against Severe Burn-Induced Distant Organ Injury: A Systematic Review and Meta-Analysis of Experimental Studies.Antioxidants (Basel, Switzerland) · 2020Review
- Hepatic inflammation after burn injury is associated with necroptotic cell death signaling.The journal of trauma and acute care surgery · 2020Article
- The effects of astaxanthin on liver histopathology and expression of superoxide dismutase in rat aflatoxicosis.The Journal of veterinary medical science · 2019Article
- Experimental models of scald burns. A scope review.Acta cirurgica brasileira · 2019Article
- Burn-Induced Multiple Organ Injury and Protective Effect of Lutein in Rats.Inflammation · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate effects of severe burn injury (BI) in rat liver through the histopathological and inflammatory markers analysis.
methodsForty-two male Wistar rats were distributed into two groups, control (C) and subjected to scald BI (SBI). The animals were euthanized one, four and 14 d post sham or 45% of the total body surface BI. Liver fragments were submitted to histopathological, morphoquantitative (hepatocyte area and cell density), ciclooxigenase-2 (COX-2) immunoexpression, and gene expression [real-time polymerase chain reaction for tumor necrosis factor (TNF)-α, inducible nitric oxide synthase (iNOS) and caspase-3] methods.
resultsHistopathological findings showed inflammatory process in all periods investigated and hepatocyte degeneration added to increased amount of connective tissue 14 d post injury. Hepatocyte area, the density of binucleated hepatocytes and density of sinusoidal cells of SBI groups were increased when compared with control. COX-2 immunoexpression was stronger in SBI groups. No differences were found in TNF-α, iNOS and caspase-3 gene expression.
conclusionBI induces histopathological changes, upregulation of COX-2 immunoexpression, and cell proliferation in liver of rats.
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