ArticleClinical practice and epidemiology in mental health : CP & EMH2015
The Burden of Depressive and Bipolar Disorders in Celiac Disease.
Article in Clinical practice and epidemiology in mental health : CP & EMH, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- The Effects of Tyrosine Kinase Inhibitors (TKIs) in Monotherapy and with Add-on Treatments on Health-related Quality of Life of People with Chronic Myeloid Leukemia: A Systematic Review of Randomized-Controlled Trials.Clinical practice and epidemiology in mental health : CP & EMH · 2023Pooled it
- Celiac disease poses significant risk in developing depression, anxiety, headache, epilepsy, panic disorder, dysthymia: A meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Pooled it
- Gluten and its relationship with inflammation and Parkinson's Disease: A literature review.AIMS neuroscience · 2025Review
- Article
- Are Depressive Symptoms in Obstructive Sleep Apnea Attributable to a Syndrome of Dysregulation of Rhythms and Hyperactivity (DYMERS)?Journal of clinical medicine · 2024Article
- Quality of Life in Systemic Lupus Erythematosus and Other Chronic Diseases: Highlighting the Amplified Impact of Depressive Episodes.Healthcare (Basel, Switzerland) · 2024Article
- Mood Disorder Questionnaire Positivity in Systemic Lupus Erythematosus and Other Chronic Diseases including Screen Bipolar Disorders or Rhythm and Energy Dysregulation Syndromes (DYMERS).Clinical practice and epidemiology in mental health : CP & EMH · 2024Article
- The impact of MDQ positivity on quality of life impairment: Does it support the hypothesis of "Dysregulation of Mood, Energy, and Social Rhythms Syndrome" (DYMERS)?Journal of public health research · 2023Article
- Review
- The Burden of Agoraphobia in Worsening Quality of Life in a Community Survey in Italy.Psychiatry investigation · 2021Article
- An Overview of the International Literature on Health-Related Quality of Life, Mental Health and Psychosocial Issues in People with Cancer.Clinical practice and epidemiology in mental health : CP & EMH · 2021Article
- The Quality of Life of People with Solid Cancer is Less Worse than Other Diseases with better Prognosis, Except in the Presence of Depression.Clinical practice and epidemiology in mental health : CP & EMH · 2021Article
- Hypothesis: bipolar disorder is an Epstein-Barr virus-driven chronic autoimmune disease - implications for immunotherapy.Clinical & translational immunology · 2020Article
- Health Related Quality of Life in Patients with Onco-hematological Diseases.Clinical practice and epidemiology in mental health : CP & EMH · 2020Article
- Impairment of Quality of Life Associated With Lifetime Diagnosis of Post-traumatic Stress Disorder in Women - A National Survey in Italy.Clinical practice and epidemiology in mental health : CP & EMH · 2019Article
- The Prevalence of Specific Phobia by Age in an Italian Nationwide Survey: How Much Does it Affect the Quality of Life?Clinical practice and epidemiology in mental health : CP & EMH · 2019Article
- Psychiatric Comorbidity in Children and Adults with Gluten-Related Disorders: A Narrative Review.Nutrients · 2018Review
- Medical Comorbidities in Bipolar Disorder.Current psychiatry reports · 2018Review
- Article
- Psychotropic medication use among patients with celiac disease.BMC psychiatry · 2018Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction
aimsto measure the association between Celiac Disease (CD) and affective disorders, particularly Bipolar Disorder (BD), since it has not been studied yet, and to measure how much the quality of life (QoL) of a person with CD is affected by comorbidity with these disorders.
methods
designCase-control study. CASES: 60 consecutive patients with CD. CONTROLS: 240 subjects without CD, randomly selected after sex- and age-matching from a database of an epidemiological study. Psychiatric diagnoses according to DSM-IV carried out by physicians using structured interview tools (ANTAS-SCID). QoL was measured by means of SF-12.
resultsThe lifetime prevalence of Major Depressive Disorder (MDD) was higher in CD than in controls (30.0% vs 8.3%, P<0.0001) as well as Panic Disorder (PD) (18.3% vs 5.4%, P<0.001) and BD (4.3% vs 0.4%, P<0.005). Patients with CD show a lower mean score than controls on SF12 (35.8±5.7 vs. 38.2±6.4; p=0.010), but those without comorbidity with MDD, PD and BD do not. The attributable burden of CD in worsening QoL - when comorbid with these disorders - was found comparable to that of serious chronic diseases like Wilson's Disease, and lower than Multiple Sclerosis only.
conclusionMDD, PD and BD are strictly associated with CD. The comorbidity with these disorders is the key determinant of impaired quality of life in CD. Thus a preventive action on mood and anxiety disorders in patients suffering from CD is required. Moreover a screening for CD in people with affective disorders and showing key symptoms or family history of CD is recommended.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.