Evidence map›Paper›PMID 26962232›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2016

Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury.

Rodney M Ritzel, Joshua Crapser, Anita R Patel, Rajkumer Verma, Jeremy M Grenier, Anjali Chauhan, Evan R Jellison, Louise D McCullough

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 181 citations in OpenAlex.

  1. Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
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  17. T Cells Trafficking into the Brain in Aging and Alzheimer's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
    Review
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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rodney M RitzelNeuroscience Department, University of Connecticut Health Center, Farmington, CT 06030;
Joshua CrapserNeuroscience Department, University of Connecticut Health Center, Farmington, CT 06030;
Anita R PatelNeuroscience Department, University of Connecticut Health Center, Farmington, CT 06030;
Rajkumer VermaNeuroscience Department, University of Connecticut Health Center, Farmington, CT 06030;
Jeremy M GrenierImmunology Department, University of Connecticut Health Center, Farmington, CT 06030; and.
Anjali ChauhanNeuroscience Department, University of Connecticut Health Center, Farmington, CT 06030;
Evan R JellisonImmunology Department, University of Connecticut Health Center, Farmington, CT 06030; and.
Louise D McCulloughNeuroscience Department, University of Connecticut Health Center, Farmington, CT 06030; Department of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77370 Louise.D.McCullough@uth.tmc.edu.
UConn Health · USThe University of Texas Health Science Center · US

Funding

Gender Differences in Ischemic Cell DeathR01NS055215 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCCULLOUGH, LOUISE D. · 2007 to 2016
$4.3M
Psychosocial Stress and Behavioral Response to StrokeR01NS077769 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MCCULLOUGH, LOUISE D. · 2011 to 2014
$2.3M
Regulation of the microglial response to stroke.R21NS076293 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MCCULLOUGH, LOUISE D. · 2011 to 2012
$424k
The Immunoinhibitory Role of CD200-CD200R1 Signaling in Experimental StrokeF31NS083244 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RITZEL, RODNEY · 2013 to 2015
$73k
NINDS NIH HHS F31 NS083244NINDS NIH HHS F31 NS083244-01A1NINDS NIH HHS R01 NS055215NINDS NIH HHS R01 NS077769NINDS NIH HHS R21 NS076293NINDS NIH HHS R21 NS076293-01A1
6 · The paper itself

Abstract

Aging is associated with an increase in basal inflammation in the CNS and an overall decline in cognitive function and poorer recovery following injury. Growing evidence suggests that leukocyte recruitment to the CNS is also increased with normal aging, but, to date, no systematic evaluation of these age-associated leukocytes has been performed. In this work, the effect of aging on CNS leukocyte recruitment was examined. Aging was associated with more CD45(high) leukocytes, primarily composed of conventional CD8(+) T cells. These results were strain independent and seen in both sexes. Intravascular labeling and immunohistology revealed the presence of parenchymal CD8(+) T cells in several regions of the brain, including the choroid plexus and meninges. These cells had effector memory (CD44(+)CD62L(-)) and tissue-resident phenotypes and expressed markers associated with TCR activation. Analysis of TCRvβ repertoire usage suggested that entry into the CNS is most likely stochastic rather than Ag driven. Correlational analyses revealed a positive association between CD8 T cell numbers and decreased proinflammatory function of microglia. However, the effects of cerebral ischemia and ex vivo stimulation of these cells dramatically increased production of TNF, IFN-γ, and MCP-1/CCL2. Taken together, we identified a novel population of resident memory, immunosurveillant CD8 T cells that represent a hallmark of CNS aging and appear to modify microglia homeostasis under normal conditions, but are primed to potentiate inflammation and leukocyte recruitment following ischemic injury.

Indexed as

Age FactorsAgingAnimalsBiomarkersBrainCD8-Positive T-LymphocytesChemokine CCL2Disease Models, AnimalFemaleHyaluronan ReceptorsImmunologic MemoryImmunologic SurveillanceInfarction, Middle Cerebral ArteryInflammationInterferon-gammaL-SelectinBiomarkersCcl2 protein, mouseCd44 protein, mouseChemokine CCL2Hyaluronan ReceptorsInterferon-gammaL-SelectinReceptors, Antigen, T-Cell, alpha-betaTumor Necrosis Factor-alpha

Identifiers

PMID26962232
PMCPMC4868658
OpenAlexW2293892300

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.