Evidence map›Paper›PMID 26962222›Full record

ArticleJournal of virology2016

Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions.

Valentina Quercioli, Cristina Di Primio, Antonio Casini, Lubbertus C F Mulder, Lenard S Vranckx, Doortje Borrenberghs, Rik Gijsbers, Zeger Debyser, Anna Cereseto

Abstract readComparative Study
In one paragraph

Article in Journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Capsid-CPSF6 interaction: Master regulator of nuclear HIV-1 positioning and integration.Journal of life sciences (Westlake Village, Calif.) · 2019
    Article
  6. Article
  7. Article
  8. Cellular and molecular mechanisms of HIV-1 integration targeting.Cellular and molecular life sciences : CMLS · 2018
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Nuclear landscape of HIV-1 infection and integration.Nature reviews. Microbiology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Valentina QuercioliLaboratory of Biology, Scuola Normale Superiore, Pisa, Italy.
Cristina Di PrimioLaboratory of Biology, Scuola Normale Superiore, Pisa, Italy.
Antonio CasiniLaboratory of Molecular Virology, University of Trento, Centre for Integrative Biology, Trento, Italy.
Lubbertus C F MulderDepartment of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lenard S VranckxLaboratory of Molecular Virology and Gene Therapy, KU Leuven, Leuven, Flanders, Belgium.
Doortje BorrenberghsLaboratory of Molecular Virology and Gene Therapy, KU Leuven, Leuven, Flanders, Belgium.
Rik GijsbersLaboratory of Molecular Virology and Gene Therapy, KU Leuven, Leuven, Flanders, Belgium.
Zeger DebyserLaboratory of Molecular Virology and Gene Therapy, KU Leuven, Leuven, Flanders, Belgium.
Anna CeresetoLaboratory of Molecular Virology, University of Trento, Centre for Integrative Biology, Trento, Italy anna.cereseto@unitn.it.

Funding

Impact of HERV-K expression on HIV-1 life cycleR01GM113886 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MULDER, LUBBERTUS C · 2014 to 2018
$1.8M
NIGMS NIH HHS R01 GM113886
6 · The paper itself

Abstract

Recent advances in fluorescence microscopy allow three-dimensional analysis of HIV-1 preintegration complexes in the nuclei of infected cells. To extend this investigation to gammaretroviruses, we engineered a fluorescent Moloney murine leukemia virus (MLV) system consisting of MLV-integrase fused to enhanced green fluorescent protein (MLV-IN-EGFP). A comparative analysis of lentiviral (HIV-1) and gammaretroviral (MLV) fluorescent complexes in the nuclei of infected cells revealed their different spatial distributions. This research tool has the potential to achieve new insight into the nuclear biology of these retroviruses.

Indexed as

AnimalsCell NucleusGreen Fluorescent ProteinsHeLa CellsHIV-1HumansIntegrasesMiceMicroscopy, FluorescenceMoloney murine leukemia virusVirus Integrationenhanced green fluorescent proteinGreen Fluorescent ProteinsIntegrases

Identifiers

PMID26962222
PMCPMC4859700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.