Evidence map›Paper›PMID 26962217›Full record

ReviewJournal of virology2016

Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere.

Helen M Lazear, Michael S Diamond

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 300 papers.

0numbers the graph read from it
0cells of the map it votes in
300citing papers in PubMed
80.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

300 citing papers in PubMed, 448 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Vitamin D Reprograms Non-Coding RNA Networks to Block Zika Virus in Human Macrophages.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Bioprofiling and vaccine development for Zika virus.Science China. Life sciences · 2025
    Review
  11. Review
  12. Article
  13. An updated review of Zika virus vaccine development.Clinical and experimental vaccine research · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

240 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Helen M LazearDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA helen.lazear@med.unc.edu diamond@borcim.wustl.edu.
Michael S DiamondDepartments of Medicine, Molecular Microbiology, Pathology, and Immunology and The Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, Missouri, USA helen.lazear@med.unc.edu diamond@borcim.wustl.edu.
University of North Carolina at Chapel Hill · USWashington University in St. Louis · US

Funding

Antibody-based Protection against FlavivirsesR01AI073755 · NIAID · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, FREMONT, DAVED H. · 2007 to 2022
$11.4M
ISG CONTROL OF FLAVIVIRUS INFECTIONR01AI104972 · NIAID · WASHINGTON UNIVERSITY · PI CHANDA, SUMIT K, DIAMOND, MICHAEL S · 2013 to 2017
$3.0M
NIAID NIH HHS R01 AI073755NIAID NIH HHS R01 AI104972
6 · The paper itself

Abstract

Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of outbreaks accompanied by unexpectedly severe clinical complications brought this virus into the spotlight as causing an infection of global public health concern. In this review, we discuss the history and epidemiology of ZIKV infection, recent outbreaks in Oceania and the emergence of ZIKV in the Western Hemisphere, newly ascribed complications of ZIKV infection, including Guillain-Barré syndrome and microcephaly, potential interactions between ZIKV and dengue virus, and the prospects for the development of antiviral agents and vaccines.

Indexed as

AedesAnimalsDengue VirusDisease OutbreaksDisease ReservoirsFemaleGlobal HealthGuillain-Barre SyndromeHumansInfectious Disease Transmission, VerticalMicrocephalyMosquito VectorsOceaniaPregnancyPregnancy Complications, InfectiousViral VaccinesViral Vaccines

Identifiers

PMID26962217
PMCPMC4859708
OpenAlexW2294983505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.