Evidence map›Paper›PMID 26962170›Full record

ArticleJournal of oncology practice2016

Oncologists' Selection of Genetic and Molecular Testing in the Evolving Landscape of Stage II Colorectal Cancer.

Aparna R Parikh, Nancy L Keating, Pang-Hsiang Liu, Stacy W Gray, Carrie N Klabunde, Katherine L Kahn, David A Haggstrom, Sapna Syngal, Benjamin Kim

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oncology practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Aparna R ParikhUniversity of California, San Francisco, San Francisco; University of California, Los Angeles, Los Angeles; RAND Corporation, Santa Monica, CA; Harvard Medical School; Brigham and Women's Hospital; Dana-Farber Cancer Institute, Boston, MA; National Institutes of Health, Bethesda, MD; Richard L. Roudebush Veterans Affairs Medical Center; and Indiana University School of Medicine, Indianapolis, IN.
Nancy L KeatingUniversity of California, San Francisco, San Francisco; University of California, Los Angeles, Los Angeles; RAND Corporation, Santa Monica, CA; Harvard Medical School; Brigham and Women's Hospital; Dana-Farber Cancer Institute, Boston, MA; National Institutes of Health, Bethesda, MD; Richard L. Roudebush Veterans Affairs Medical Center; and Indiana University School of Medicine, Indianapolis, IN.
Pang-Hsiang LiuUniversity of California, San Francisco, San Francisco; University of California, Los Angeles, Los Angeles; RAND Corporation, Santa Monica, CA; Harvard Medical School; Brigham and Women's Hospital; Dana-Farber Cancer Institute, Boston, MA; National Institutes of Health, Bethesda, MD; Richard L. Roudebush Veterans Affairs Medical Center; and Indiana University School of Medicine, Indianapolis, IN.
Stacy W GrayUniversity of California, San Francisco, San Francisco; University of California, Los Angeles, Los Angeles; RAND Corporation, Santa Monica, CA; Harvard Medical School; Brigham and Women's Hospital; Dana-Farber Cancer Institute, Boston, MA; National Institutes of Health, Bethesda, MD; Richard L. Roudebush Veterans Affairs Medical Center; and Indiana University School of Medicine, Indianapolis, IN.
Carrie N KlabundeUniversity of California, San Francisco, San Francisco; University of California, Los Angeles, Los Angeles; RAND Corporation, Santa Monica, CA; Harvard Medical School; Brigham and Women's Hospital; Dana-Farber Cancer Institute, Boston, MA; National Institutes of Health, Bethesda, MD; Richard L. Roudebush Veterans Affairs Medical Center; and Indiana University School of Medicine, Indianapolis, IN.
Katherine L KahnUniversity of California, San Francisco, San Francisco; University of California, Los Angeles, Los Angeles; RAND Corporation, Santa Monica, CA; Harvard Medical School; Brigham and Women's Hospital; Dana-Farber Cancer Institute, Boston, MA; National Institutes of Health, Bethesda, MD; Richard L. Roudebush Veterans Affairs Medical Center; and Indiana University School of Medicine, Indianapolis, IN.
David A HaggstromUniversity of California, San Francisco, San Francisco; University of California, Los Angeles, Los Angeles; RAND Corporation, Santa Monica, CA; Harvard Medical School; Brigham and Women's Hospital; Dana-Farber Cancer Institute, Boston, MA; National Institutes of Health, Bethesda, MD; Richard L. Roudebush Veterans Affairs Medical Center; and Indiana University School of Medicine, Indianapolis, IN.
Sapna SyngalUniversity of California, San Francisco, San Francisco; University of California, Los Angeles, Los Angeles; RAND Corporation, Santa Monica, CA; Harvard Medical School; Brigham and Women's Hospital; Dana-Farber Cancer Institute, Boston, MA; National Institutes of Health, Bethesda, MD; Richard L. Roudebush Veterans Affairs Medical Center; and Indiana University School of Medicine, Indianapolis, IN.
Benjamin KimUniversity of California, San Francisco, San Francisco; University of California, Los Angeles, Los Angeles; RAND Corporation, Santa Monica, CA; Harvard Medical School; Brigham and Women's Hospital; Dana-Farber Cancer Institute, Boston, MA; National Institutes of Health, Bethesda, MD; Richard L. Roudebush Veterans Affairs Medical Center; and Indiana University School of Medicine, Indianapolis, IN benjamin.kim@ucsf.edu.
Harvard University · USIndiana University School of MedicineNational Institutes of Health · USDana-Farber Cancer Institute · USIndiana University – Purdue University Indianapolis · USRAND Corporation · USBrigham and Women's Hospital · US

Funding

PROPENSITY SCORES IN HIERARCHICAL MODELSU01CA093344 · NCI · DANA-FARBER CANCER INSTITUTE · PI AYANIAN, JOHN Z., FOUAD, MONA N. · 2001 to 2011
$19.5M
Behavioral Economics and Improving Chemotherapy Decisions for Advanced CancerK24CA181510 · NCI · HARVARD MEDICAL SCHOOL · PI KEATING, NANCY L · 2014 to 2018
$867k
NCI NIH HHS 5U01CA093344-08NCI NIH HHS K24 CA181510NCI NIH HHS K24CA181510NCI NIH HHS U01 CA093344PHS HHS K24113433
6 · The paper itself

Abstract

purposeLittle is known about the roles of genetic and molecular testing and Lynch syndrome screening in the formulation of predictive and prognostic assessments for patients with stage II colorectal cancer (CRC).

methodsFrom 2012 to 2013, we surveyed medical oncologists in the Cancer Care Outcomes Research and Surveillance Consortium and evaluated oncologists' selection of microsatellite instability (MSI) and/or immunohistochemistry (IHC) for mismatch repair (MMR) proteins, germline testing for MMR genes, BRAF and KRAS mutation analysis, and Oncotype DX in stage II CRC. Physicians were randomly assigned to receive one of three vignettes that varied by strength of CRC family history. We used multivariable logistic regression to identify physician and practice characteristics associated with test selection.

resultsAmong 327 oncologists, MSI and/or IHC for MMR proteins were most frequently selected (n = 205; 64%), with 82% versus 53% choosing MSI/IHC testing in patients with strong versus no CRC family history, respectively (adjusted odds ratio [OR], 3.87; 95% CI, 2.07 to 7.22). KRAS and Oncotype DX testing were chosen by 24% and 38% of oncologists, respectively. Graduates of non-US and Canadian medical schools and physicians compensated by fee-for-service or on the basis of productivity were more likely to choose KRAS testing versus those receiving salaries not on the basis of productivity (OR, 2.16; 95% CI, 1.17 to 3.99; and OR, 1.94; 95% CI, 1.02 to 3.66, respectively). Fee-for-service or productivity-based salaries were also associated with increased odds of Oncotype DX testing (OR, 2.04; 95% CI, 1.17 to 3.55).

conclusionAmong surveyed oncologists, we found undertesting and overtesting related to genetic and molecular testing and Lynch syndrome screening for patients with stage II CRC,highlighting the need for improved implementation, targeted education, and evaluation of organizational and financial arrangements to promote the appropriate use of such tests.

Indexed as

Molecular Diagnostic TechniquesColorectal NeoplasmsGenetic TestingHealth Care SurveysHumansMiddle AgedNeoplasm StagingOncologistsPractice Patterns, Physicians'

Identifiers

PMID26962170
PMCPMC4960467
OpenAlexW2300594175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.