ArticleHuman molecular genetics2016
Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease.
Article in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 5 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 5 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Periodontal infectogenomics: a systematic review update of associations between host genetic variants and subgingival microbial detection.Clinical oral investigations · 2022Pooled it
- Identification of novel genome-wide pleiotropic associations with oral inflammatory traits.Molecular genetics and genomics : MGG · 2022Pooled it
- Pooled it
- Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.Nature communications · 2019Pooled it
- Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci.European journal of human genetics : EJHG · 2019Pooled it
- Precision periodontology in clinical practice: bridging omics and clinical decision-making.Clinical oral investigations · 2026Review
- Chronic periodontitis and respiratory diseases: A bidirectional two-sample Mendelian randomization study.Medicine · 2026Article
- From oral infection to pulmonary inflammation: periodontal pathogens and their potential role in COPD susceptibility.Frontiers in cellular and infection microbiology · 2026Article
- Inflammasome targeting for periodontitis prevention is sex dependent.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Endpoints of Periodontal Therapy in Elderly Patients With Stage III/IV Periodontitis and Their Oral Health-Related Quality of Life Following 10 Years of Supportive Periodontal Therapy.Journal of clinical periodontology · 2025Article
- Full-length 16S rRNA sequencing reveals microbial characteristics in supragingival plaque of periodontitis patients.Journal of dental sciences · 2025Article
- The 2-Step Mendelian Randomisation Study Assesses Genetic Causality and Potential Mediators of Periodontal Disease and Atrial Fibrillation.International dental journal · 2025Article
- New approaches to the control of chronic inflammatory diseases with a focus on the endolysosomal system of immune cells.International immunology · 2024Review
- Periodontal disease increases the severity of chronic obstructive pulmonary disease: a Mendelian randomization study.BMC pulmonary medicine · 2024Article
- Article
- The Proteomes of Oral Cells Change during Co-Cultivation withBiomedicines · 2023Article
- TRAF3IP2-IL-17 Axis Strengthens the Gingival Defense against Pathogens.Journal of dental research · 2023Article
- Association between periodontitis and COVID-19 infection: a two-sample Mendelian randomization study.PeerJ · 2023Article
- UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells.Molecular and cellular biology · 2022Article
- Therapeutic and Metagenomic Potential of the Biomolecular Therapies against Periodontitis and the Oral Microbiome: Current Evidence and Future Perspectives.International journal of molecular sciences · 2022Review
9 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
Genome-wide association studies (GWAS) of chronic periodontitis (CP) defined by clinical criteria alone have had modest success to-date. Here, we refine the CP phenotype by supplementing clinical data with biological intermediates of microbial burden (levels of eight periodontal pathogens) and local inflammatory response (gingival crevicular fluid IL-1β) and derive periodontal complex traits (PCTs) via principal component analysis. PCTs were carried forward to GWAS (∼2.5 million markers) to identify PCT-associated loci among 975 European American adult participants of the Dental ARIC study. We sought to validate these findings for CP in the larger ARIC cohort (n = 821 participants with severe CP, 2031-moderate CP, 1914-healthy/mild disease) and an independent German sample including 717 aggressive periodontitis cases and 4210 controls. We identified six PCTs with distinct microbial community/IL-1β structures, although with overlapping clinical presentations. PCT1 was characterized by a uniformly high pathogen load, whereas PCT3 and PCT5 were dominated by Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, respectively. We detected genome-wide significant signals for PCT1 (CLEC19A, TRA, GGTA2P, TM9SF2, IFI16, RBMS3), PCT4 (HPVC1) and PCT5 (SLC15A4, PKP2, SNRPN). Overall, the highlighted loci included genes associated with immune response and epithelial barrier function. With the exception of associations of BEGAIN with severe and UBE3D with moderate CP, no other loci were associated with CP in ARIC or aggressive periodontitis in the German sample. Although not associated with current clinically determined periodontal disease taxonomies, upon replication and mechanistic validation these candidate loci may highlight dysbiotic microbial community structures and altered inflammatory/immune responses underlying biological sub-types of CP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.