ArticleProceedings. Biological sciences2016
Selection for brain size impairs innate, but not adaptive immune responses.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Experimental expansion of relative telencephalon size improves the main executive function abilities in guppy.PNAS nexus · 2023Article
- Divergence in brain size and brain region volumes across wild guppy populations.Proceedings. Biological sciences · 2022Article
- Linking omega-3 polyunsaturated fatty acids in natural diet with brain size of wild consumers.Oecologia · 2022Article
- Rapid mosaic brain evolution under artificial selection for relative telencephalon size in the guppy (Science advances · 2021Article
- Brain size variation along altitudinal gradients in the Asiatic Toad (Ecology and evolution · 2021Article
- Microglial Morphology Across Distantly Related Species: Phylogenetic, Environmental and Age Influences on Microglia Reactivity and Surveillance States.Frontiers in immunology · 2021Review
- A weapons-testes trade-off in males is amplified in female traits.Proceedings. Biological sciences · 2019Article
- Annual variation in predation risk is related to the direction of selection for brain size in the wild.Scientific reports · 2019Article
- No gains for bigger brains: Functional and neuroanatomical consequences of relative brain size in a parasitic wasp.Journal of evolutionary biology · 2019Article
- Large brains, short life: selection on brain size impacts intrinsic lifespan.Biology letters · 2019Article
- Early neurogenomic response associated with variation in guppy female mate preference.Nature ecology & evolution · 2018Article
- Measuring and understanding individual differences in cognition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Testing ontogenetic patterns of sexual size dimorphism against expectations of the expensive tissue hypothesis, an intraspecific example using oyster toadfish (Ecology and evolution · 2018Article
- Seasonality and brain size are negatively associated in frogs: evidence for the expensive brain framework.Scientific reports · 2017Article
- Female brain size affects the assessment of male attractiveness during mate choice.Science advances · 2017Article
- Endocranial volume is heritable and is associated with longevity and fitness in a wild mammal.Royal Society open science · 2016Article
- Body condition reveals hidden correlations between co-infection and behavior in sunfish.Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
- On the role of body size, brain size, and eye size in visual acuity.Behavioral ecology and sociobiologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both the brain and the immune system are energetically demanding organs, and when natural selection favours increased investment into one, then the size or performance of the other should be reduced. While comparative analyses have attempted to test this potential evolutionary trade-off, the results remain inconclusive. To test this hypothesis, we compared the tissue graft rejection (an assay for measuring innate and acquired immune responses) in guppies (Poecilia reticulata) artificially selected for large and small relative brain size. Individual scales were transplanted between pairs of fish, creating reciprocal allografts, and the rejection reaction was scored over 8 days (before acquired immunity develops). Acquired immune responses were tested two weeks later, when the same pairs of fish received a second set of allografts and were scored again. Compared with large-brained animals, small-brained animals of both sexes mounted a significantly stronger rejection response to the first allograft. The rejection response to the second set of allografts did not differ between large- and small-brained fish. Our results show that selection for large brain size reduced innate immune responses to an allograft, which supports the hypothesis that there is a selective trade-off between investing into brain size and innate immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.