ArticleJournal of clinical microbiology2016
Multicenter Evaluation of Clinical Diagnostic Methods for Detection and Isolation of Campylobacter spp. from Stool.
Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Comparative Performance and Species-Specific Recovery Biases of Culture-Based Methods forVeterinary sciences · 2026Review
- GeoSentinel Analysis of Travelers' Diarrhea Antimicrobial Resistance Patterns.JAMA network open · 2025Article
- Low cost and real-time surveillance of enteric infection and diarrhoeal disease using rapid diagnostic tests in Cox's Bazar, Bangladesh.Conflict and health · 2024Article
- Capturing clinically relevantMicrobial genomics · 2024Article
- Diagnostic performance of microscopic stool examination inJournal of general and family medicine · 2023Article
- "Candidatus Campylobacter infans" detection is not associated with diarrhea in children under the age of 2 in Peru.PLoS neglected tropical diseases · 2022Article
- Genome Sequence Analysis and Characterization of Shiga Toxin 2 Production byFrontiers in cellular and infection microbiology · 2022Article
- Evidence of False Positivity forOpen forum infectious diseases · 2021Article
- Comparison of several Real-Time PCR Kits versus a Culture-dependent Algorithm to Identify Enteropathogens in Stool Samples.Scientific reports · 2020Article
- Whole-Genome Sequencing and Bioinformatic Analysis of Environmental, Agricultural, and HumanFrontiers in microbiology · 2020Article
- Campylobacter culture fails to correctly detect Campylobacter in 30% of positive patient stool specimens compared to non-cultural methods.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- The Brief Case: Postinfectious Glomerulonephritis as an Unexpected Sequela of Drinking Raw Milk.Journal of clinical microbiology · 2019Article
- Impact of Culture-Independent Diagnostic Testing on Recovery of Enteric Bacterial Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Observational
- Evaluation of the Diagnostic Accuracy of Two Immunochromatographic Tests Detecting Campylobacter in Stools and Their Role in Campylobacter Infection Diagnosis.Journal of clinical microbiology · 2018Article
- New Developments in Rapid Diagnostic Testing for Children.Infectious disease clinics of North America · 2018Review
- Unforeseen Consequences: Culture-Independent Diagnostic Tests and Epidemiologic Tracking of Foodborne Pathogens.Journal of clinical microbiology · 2017Article
- Incidence and Trends of Infections with Pathogens Transmitted Commonly Through Food and the Effect of Increasing Use of Culture-Independent Diagnostic Tests on Surveillance - Foodborne Diseases Active Surveillance Network, 10 U.S. Sites, 2013-2016.MMWR. Morbidity and mortality weekly report · 2017Article
- Evaluation of the BioFire FilmArray® GastrointestinalPanel in a Midwestern Academic Hospital.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Clinical Microbiology Laboratories' Adoption of Culture-Independent Diagnostic Tests Is a Threat to Foodborne-Disease Surveillance in the United States.Journal of clinical microbiology · 2017Article
- Metagenomics: The Next Culture-Independent Game Changer.Frontiers in microbiology · 2017Review
Corrections and comments
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Authors and funding
33 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of culture-independent diagnostic tests (CIDTs), such as stool antigen tests, as standalone tests for the detection of Campylobacter in stool is increasing. We conducted a prospective, multicenter study to evaluate the performance of stool antigen CIDTs compared to culture and PCR for Campylobacter detection. Between July and October 2010, we tested 2,767 stool specimens from patients with gastrointestinal illness with the following methods: four types of Campylobacter selective media, four commercial stool antigen assays, and a commercial PCR assay. Illnesses from which specimens were positive by one or more culture media or at least one CIDT and PCR were designated "cases." A total of 95 specimens (3.4%) met the case definition. The stool antigen CIDTs ranged from 79.6% to 87.6% in sensitivity, 95.9 to 99.5% in specificity, and 41.3 to 84.3% in positive predictive value. Culture alone detected 80/89 (89.9% sensitivity) Campylobacter jejuni/Campylobacter coli-positive cases. Of the 209 noncases that were positive by at least one CIDT, only one (0.48%) was positive by all four stool antigen tests, and 73% were positive by just one stool antigen test. The questionable relevance of unconfirmed positive stool antigen CIDT results was supported by the finding that noncases were less likely than cases to have gastrointestinal symptoms. Thus, while the tests were convenient to use, the sensitivity, specificity, and positive predictive value of Campylobacter stool antigen tests were highly variable. Given the relatively low incidence of Campylobacter disease and the generally poor diagnostic test characteristics, this study calls into question the use of commercially available stool antigen CIDTs as standalone tests for direct detection of Campylobacter in stool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.