Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2016
Toward improved phosphorus efficiency in monogastrics-interplay of serum, minerals, bone, and immune system after divergent dietary phosphorus supply in swine.
Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Association of serum 25(OH)D with Cathepsin K levels in gingival crevicular fluid and saliva in periodontal health and disease: a cross-sectional study.BMC oral health · 2026Article
- Effects of dietary supplementation of Escherichia coli 6-phytase levels on growth performance, nutrient digestibility, and blood inositol in weanling piglets.Animal bioscience · 2026Article
- Parathyroid glands exhibit reduced parenchymatic chief cells and increased extracellular collagen as a response to a long-term low-phosphorus diet in pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Microbial phytase and 25-hydroxy-vitamin D3 fed to growing pigs increase digestibility of calcium and phosphorus and influence plasma vitamin D metabolites and serum bone biomarkers, but effects are not always additive.Journal of animal science · 2025Article
- Long-Term Effects of Early Low-Phosphorous Nutritional Conditioning on Broiler Chicken Performance, Bone Mineralization, and Gut Health Under Adequate or Phosphorous-Deficient Diets.Animals : an open access journal from MDPI · 2024Article
- The effect of bone and analytical methods on the assessment of bone mineralization response to dietary phosphorus, phytase, and vitamin D in nursery pigs.Journal of animal science · 2023Article
- Efficacy of a bacterial 6-phytase supplemented beyond traditional dose levels on jejunal mucosa-associated microbiota, ileal nutrient digestibility, bone parameters, and intestinal health, and growth performance of nursery pigs.Journal of animal science · 2023Article
- Phosphorus nutrition of growing pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- A time-series effect of phytase supplementation on phosphorus utilization in growing and finishing pigs fed a low-phosphorus diet.Journal of animal science · 2022Article
- mRNA Profiles of Porcine Parathyroid Glands Following Variable Phosphorus Supplies throughout Fetal and Postnatal Life.Biomedicines · 2021Article
- Evaluation of serum parameters to predict the dietary intake of calcium and available phosphorus in growing pigs.Translational animal science · 2021Article
- Biochemistry and Immune Biomarkers Indicate Interacting Effects of Pre- and Postnatal Stressors in Pigs across Sexes.Animals : an open access journal from MDPI · 2021Article
- The Relationship Between Osteoporosis and Intestinal Microbes in the Henan Province of China.Frontiers in cell and developmental biology · 2021Article
- Adverse effects on growth performance and bone development in nursery pigs fed diets marginally deficient in phosphorus with increasing calcium to available phosphorus ratios.Journal of animal science · 2020Article
- Influence of Phytase Supplementation at Increasing Doses from 0 to 1500 FTU/kg on Growth Performance, Nutrient Digestibility, and Bone Status in Grower-Finisher Pigs Fed Phosphorus-Deficient Diets.Animals : an open access journal from MDPI · 2020Article
- Identification of the Key Molecular Drivers of Phosphorus Utilization Based on Host miRNA-mRNA and Gut Microbiome Interactions.International journal of molecular sciences · 2020Article
- Ileal Transcriptome Profiles of Japanese Quail Divergent in Phosphorus Utilization.International journal of molecular sciences · 2020Article
- Tissue-Wide Gene Expression Analysis of Sodium/Phosphate Co-Transporters in Pigs.International journal of molecular sciences · 2019Article
- Physiological and Transcriptional Responses in Weaned Piglets Fed Diets with Varying Phosphorus and Calcium Levels.Nutrients · 2019Article
- Genetic variants of major genes contributing to phosphate and calcium homeostasis and their association with serum parameters in pigs.Journal of applied genetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphorus (P) is of vital importance for many aspects of metabolism, including bone mineralization, blood buffering, and energy utilization. In order to identify molecular routes affecting intrinsic P utilization, we address processes covering P intake, uptake, metabolism, and excretion. In particular, the interrelation of bone tissue and immune features is of interest to approximate P intake to animal's physiology and health status. German Landrace piglets received different levels of digestible phosphorus: recommended, higher, or lower amounts. At multiple time points, relevant serum parameters were analyzed and radiologic studies on bone characteristics were performed. Peripheral blood mononuclear cells were collected to assess differential gene expression. Dietary differences were reflected by serum phosphorus, calcium, parathyroid hormone, and vitamin D. Bone reorganization was persistently affected as shown by microstructural parameters, cathepsin K levels, and transcripts associated with bone formation. Moreover, blood expression patterns revealed a link to immune response, highlighting bidirectional loops comprising bone formation and immune features, where the receptor-activator of NF-κB ligand/receptor-activator of NF-κB kinase system may play a prominent role. The modulated P supplementation provoked considerable organismal plasticity. Genes found to be differentially expressed due to variable P supply are involved in pathways relevant to P utilization and are potential candidate genes for improved P efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.