ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Top-Down-Mediated Facilitation in the Visual Cortex Is Gated by Subcortical Neuromodulation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
- Dysfunctional neural dynamics associated with sensory phenotypes in Fragile X syndrome: insights from mouse models.Journal of neurodevelopmental disorders · 2025Review
- On Temporal Robustness & Brain-State Stability of Functional Connectivity in Mouse Primary Visual Area V1 compared to Higher Visual Area AL.bioRxiv : the preprint server for biology · 2025Article
- Hierarchical Neural Circuit Theory of Normalization and Inter-areal Communication.bioRxiv : the preprint server for biology · 2025Article
- Article
- How 'visual' is the visual cortex? The interactions between the visual cortex and other sensory, motivational and motor systems as enabling factors for visual perception.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Article
- Selective enhancement of neural coding in V1 underlies fine-discrimination learning in tree shrew.Current biology : CB · 2022Article
- Article
- Higher order visual areas enhance stimulus responsiveness in mouse primary visual cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Existing function in primary visual cortex is not perturbed by new skill acquisition of a non-matched sensory task.Nature communications · 2022Article
- Effects of top-down influence suppression on behavioral and V1 neuronal contrast sensitivity functions in cats.iScience · 2022Article
- A Cortico-Cortical Pathway Targets Inhibitory Interneurons and Modulates Paw Movement during Locomotion in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Decontextualized learning for interpretable hierarchical representations of visual patterns.Patterns (New York, N.Y.) · 2021Article
- Mouse Higher Visual Areas Provide Both Distributed and Specialized Contributions to Visually Guided Behaviors.Current biology : CB · 2020Article
- Principles of Corticocortical Communication: Proposed Schemes and Design Considerations.Trends in neurosciences · 2020Review
- Interocular velocity cues elicit vergence eye movements in mice.Journal of neurophysiology · 2020Article
- Reward Association Enhances Stimulus-Specific Representations in Primary Visual Cortex.Current biology : CB · 2020Article
- Characterization of Feedback Neurons in the High-Level Visual Cortical Areas That Project Directly to the Primary Visual Cortex in the Cat.Frontiers in neuroanatomy · 2020Article
- Article
- The Visual Cortex in Context.Annual review of vision science · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Response properties in primary sensory cortices are highly dependent on behavioral state. For example, the nucleus basalis of the forebrain plays a critical role in enhancing response properties of excitatory neurons in primary visual cortex (V1) during active exploration and learning. Given the strong reciprocal connections between hierarchically arranged cortical regions, how are increases in sensory response gain constrained to prevent runaway excitation? To explore this, we used in vivo two-photon guided cell-attached recording in conjunction with spatially restricted optogenetic photo-inhibition of higher-order visual cortex in mice. We found that the principle feedback projection to V1 originating from the lateral medial area (LM) facilitated visual responses in layer 2/3 excitatory neurons by ∼20%. This facilitation was reduced by half during basal forebrain activation due to differential response properties between LM and V1. Our results demonstrate that basal-forebrain-mediated increases in response gain are localized to V1 and are not propagated to LM and establish that subcortical modulation of visual cortex is regionally distinct.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.