ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Human Choice Strategy Varies with Anatomical Projections from Ventromedial Prefrontal Cortex to Medial Striatum.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Goal commitment is supported by vmPFC through selective attention.Nature human behaviour · 2024Article
- Prefrontal signals precede striatal signals for biased credit assignment in motivational learning biases.Nature communications · 2024Article
- Action slips in food choices: A measure of habits and goal-directed control.Learning & behavior · 2023Article
- Cognitive and neural bases of visual-context-guided decision-making.NeuroImage · 2023Article
- Advanced Reinforcement Learning and Its Connections with Brain Neuroscience.Research (Washington, D.C.) · 2023Article
- Stress-sensitive inference of task controllability.Nature human behaviour · 2022Article
- Whole-Brain Functional Connectivity Dynamics Associated With Electroconvulsive Therapy Treatment Response.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Model-based learning retrospectively updates model-free values.Scientific reports · 2022Article
- Linear reinforcement learning in planning, grid fields, and cognitive control.Nature communications · 2021Article
- Direct Approach or Detour: A Comparative Model of Inhibition and Neural Ensemble Size in Behavior Selection.Frontiers in systems neuroscience · 2021Article
- Hemispheric Asymmetry of Globus Pallidus Relates to Alpha Modulation in Reward-Related Attentional Tasks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control.eLife · 2019Article
- Hierarchical Bayesian inference for concurrent model fitting and comparison for group studies.PLoS computational biology · 2019Article
- Multimodal imaging of brain connectivity reveals predictors of individual decision strategy in statistical learning.Nature human behaviour · 2019Article
- Emotionally Aversive Cues Suppress Neural Systems Underlying Optimal Learning in Socially Anxious Individuals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Regional structural hypo- and hyperconnectivity of frontal-striatal and frontal-thalamic pathways in behavioral variant frontotemporal dementia.Human brain mapping · 2018Article
- Article
- Short-term reward experience biases inference despite dissociable neural correlates.Nature communications · 2017Article
- The Intersection between Ocular and Manual Motor Control: Eye-Hand Coordination in Acquired Brain Injury.Frontiers in neurology · 2017Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two distinct systems, goal-directed and habitual, support decision making. It has recently been hypothesized that this distinction may arise from two computational mechanisms, model-based and model-free reinforcement learning, neuronally implemented in frontostriatal circuits involved in learning and behavioral control. Here, we test whether the relative strength of anatomical connectivity within frontostriatal circuits accounts for variation in human individuals' reliance on model-based and model-free control. This hypothesis was tested by combining diffusion tensor imaging with a multistep decision task known to distinguish model-based and model-free control in humans. We found large interindividual differences in the degree of model-based control, and those differences are predicted by the structural integrity of white-matter tracts from the ventromedial prefrontal cortex to the medial striatum. Furthermore, an analysis based on masking out of bottom-up tracts suggests that this effect is driven by top-down influences from ventromedial prefrontal cortex to medial striatum. Our findings indicate that individuals with stronger afferences from the ventromedial prefrontal cortex to the medial striatum are more likely to rely on a model-based strategy to control their instrumental actions. These findings suggest a mechanism for instrumental action control through which medial striatum determines, at least partly, the relative contribution of model-based and model-free systems during decision-making according to top-down model-based information from the ventromedial prefrontal cortex. These findings have important implications for understanding the neural circuitry that might be susceptible to pathological computational processes in impulsive/compulsive psychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.