ArticleThe American journal of clinical nutrition2016
Sugar-sweetened beverage intake, chromosome 9p21 variants, and risk of myocardial infarction in Hispanics.
Article in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Interactions between genetic and lifestyle factors on cardiometabolic disease-related outcomes in Latin American and Caribbean populations: A systematic review.Frontiers in nutrition · 2023Pooled it
- Gene-diet interactions and cardiovascular diseases: a systematic review of observational and clinical trials.BMC cardiovascular disorders · 2022Pooled it
- CDKN2B-AS1 gene rs4977574 A/G polymorphism and coronary heart disease: A meta-analysis of 40,979 subjects.Journal of cellular and molecular medicine · 2021Pooled it
- Pooled it
- Pooled it
- Sugar-sweetened beverage consumption and risk of premature coronary artery disease in a multi-ethnic Iranian case-control study.Nutrition & metabolism · 2025Article
- Ethnicity modifies the relationship between added sugars and fructose exposure in the first 1000 days and offspring body composition at 24 months.Nutrition research (New York, N.Y.) · 2025Article
- Interactions Between Genetic Risk Score and Healthy Plant Diet Index on Cardiometabolic Risk Factors Among Obese and Overweight Women.Clinical nutrition research · 2023Article
- Review
- Article
- Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?International journal of molecular sciences · 2021Review
- Genetic susceptibility, plant-based dietary patterns, and risk of cardiovascular disease.The American journal of clinical nutrition · 2020Article
- The Mediterranean diet reduces the genetic risk of chromosome 9p21 for myocardial infarction in an Asian population community cohort.Scientific reports · 2019Article
- Deciphering the Riddles in Nutrition and Cardiovascular Disease.European cardiology · 2019Review
- Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk.Current cardiology reports · 2019Review
- Review
- Impact of Genes and Environment on Obesity and Cardiovascular Disease.Endocrinology · 2019Review
- Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2018Review
- Fruit and Juice Epigenetic Signatures Are Associated with Independent Immunoregulatory Pathways.Nutrients · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChromosome 9p21 variants are among the most robust genetic markers for coronary artery disease (CAD), and previous studies have suggested that genetic effects of this locus might be modified by dietary factors. Intake of sugar-sweetened beverages (SSBs), which are the main dietary source of added sugar, has been shown to interact with genetic factors in affecting CAD risk factors such as obesity.
objectiveWe aimed to test whether SSB intake modified the association between chromosome 9p21 variants and CAD risk in Hispanics living in Costa Rica.
designThe current study included 1560 incident cases of nonfatal myocardial infarction (MI) and 1751 population-based controls. Three independent single nucleotide polymorphisms (SNPs) at the chromosome 9p21 locus were genotyped. SSB intake was assessed with the use of a food-frequency questionnaire and was defined as the frequency of intake of daily servings of sweetened beverages and fruit juice.
resultsWe showed a significant interaction between SSB intake and one of the 3 variants (i.e., rs4977574) on MI risk. The per–risk allele OR (95% CI) of rs4977574 for MI was 1.44 (1.19, 1.74) in participants with higher SSB consumption (>2 servings/d), 1.21 (1.00, 1.47) in those with average consumption (1–2 servings/d), and 0.97 (0.81, 1.16) in subjects with lower consumption (<1 serving/d; P-interaction = 0.005). A genetic risk score derived from the sum of risk alleles of the 3 SNPs also showed a significant interaction with SSB intake on MI risk (P-interaction = 0.03).
conclusionOur data suggest that unhealthy dietary habits such as higher intake of SSBs could exacerbate the effects of chromosome 9p21 variants on CAD.
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Registered trials
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