ArticleEuropean journal of endocrinology2016
The Hypercoagulable state in Hyperthyroidism is mediated via the Thyroid Hormone β Receptor pathway.
Article in European journal of endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Fibrinogen and D-dimer alterations in thyroid dysfunction: implications for bleeding and thrombotic risk.Thyroid research · 2026Review
- Association Between Thyrotoxicosis and Cerebral Venous Thrombosis.Journal of clinical medicine · 2024Review
- The genetic effects of hormones modulated by the Pituitary-Thyroid/Adrenal/Gonadal axis on the risk of developing venous thromboembolism: a mendelian randomization study.BMC cardiovascular disorders · 2024Article
- Associations between deep venous thrombosis and thyroid diseases: a two-sample bidirectional Mendelian randomization study.European journal of medical research · 2024Article
- Functional enrichment analysis of mutated genes in children with hyperthyroidism.Frontiers in endocrinology · 2023Article
- Yearly Incidence of Stroke and Bleeding in Atrial Fibrillation with Concomitant Hyperthyroidism: A National Discharge Database Study.Journal of clinical medicine · 2022Article
- Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study.Thyroid : official journal of the American Thyroid Association · 2021Article
- Dyslipidemia, Insulin Resistance, Ectopic Lipid Accumulation, and Vascular Function in Resistance to Thyroid Hormone β.The Journal of clinical endocrinology and metabolism · 2021Article
- Cardiovascular effects of overt and subclinical hyperthyroidism: focus on differentiated thyroid cancer.Endocrine connections · 2021Review
- Triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis.Archives of medical science : AMS · 2020Article
- New Interfaces of Thyroid Hormone Actions With Blood Coagulation and Thrombosis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Review
- Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age-related increase of VWF in von Willebrand disease.British journal of haematology · 2018Article
- Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model.BMC medicine · 2017Article
- Hyperthyroidism as a Precipitant Factor for Cerebral Venous Thrombosis: A Case Report.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveHyperthyroidism is associated with a hypercoagulable state, but the underlying mechanism is unknown. Patients with resistance to thyroid hormone (RTH) due to defective thyroid hormone receptor β (TRβ) exhibit elevated circulating thyroid hormones (TH) with refractoriness to TH action in TRβ-expressing tissues. We tested the hypothesis that the hypercoagulable state in hyperthyroidism is mediated via the TRβ.
designWe conducted a cross-sectional study from November 2013 to January 2015 in 3 hospitals in the Netherlands and the United Kingdom.
methodsPatients with RTH due to defective TRβ (n=18), patients with hyperthyroidism (n=16) and euthyroid subjects (n=18) were included. TH concentrations and markers of coagulation and fibrinolysis were measured. Data are expressed as median [interquartile range].
resultsFree thyroxine (FT4) levels were slightly higher in hyperthyroid patients than in RTH patients (53.9 [30.5-70.0] and 34.9 [28.4-42.2]pmol/l, respectively, P=0.042). Both groups had raised FT4 levels compared to euthyroid subjects (14.0 [13.0-15.8] pmol/l, P≤0.001). Levels of von Willebrand factor (VWF), factor (F) VIII, fibrinogen, and D-dimer were significantly higher in hyperthyroid patients than in RTH patients (VWF 231 [195-296] vs. 111 [82-140]%, FVIII 215 [192-228] vs. 145 [97-158]%, fibrinogen 3.6 [3.0-4.4] vs. 2.8 [2.5-3.2]g/L, D-dimer 0.41 [0.31-0.88] vs. 0.20 [0.17-0.26]mg/L, respectively, P≤0.001), while there were no differences between RTH patients and euthyroid controls.
conclusionsParameters of coagulation and fibrinolysis were elevated in hyperthyroid patients compared to patients with RTH due to defective TRβ, whereas these parameters were not different between euthyroid controls and RTH patients, despite elevated FT4 concentrations in RTH patients. This indicates that the procoagulant effects observed in hyperthyroidism are mediated via the TRβ.
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