Evidence map›Paper›PMID 26961776›Full record

ArticleRadiation and environmental biophysics2016

A study on the effect of the internal exposure to (210)Po on the excretion of urinary proteins in rats.

Baki Sadi, Chunsheng Li, Raymond Ko, Joseph Daka, Hamdi Yusuf, Heather Wyatt, Joel Surette, Nick Priest, Nobuyuki Hamada

Abstract read
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In one paragraph

Article in Radiation and environmental biophysics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Baki SadiNational Internal Radiation Assessment Section, Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, ON, K1A 1C1, Canada. baki.sadi@hc-sc.gc.ca.
Chunsheng LiNational Internal Radiation Assessment Section, Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, ON, K1A 1C1, Canada.
Raymond KoNational Internal Radiation Assessment Section, Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, ON, K1A 1C1, Canada.
Joseph DakaNational Internal Radiation Assessment Section, Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, ON, K1A 1C1, Canada.
Hamdi YusufDepartment of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Heather WyattCanadian Nuclear Laboratories, Atomic Energy of Canada Limited, Chalk River, ON, K0J 1J0, Canada.
Joel SuretteCanadian Nuclear Laboratories, Atomic Energy of Canada Limited, Chalk River, ON, K0J 1J0, Canada.
Nick PriestCanadian Nuclear Laboratories, Atomic Energy of Canada Limited, Chalk River, ON, K0J 1J0, Canada.
Nobuyuki HamadaNuclear Technology Research Laboratory, Radiation Safety Research Center, Central Research Institute of Electric Power Industry (CRIEPI), 2-11-1 Iwado-kita, Komae, Tokyo, 201-8511, Japan.
Health Canada · CAAtomic Energy (Canada) · CACarleton University · CACentral Research Institute of Electric Power Industry · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was designed to assess the feasibility of a noninvasive urine specimen for the detection of proteins as indicators of internal exposure to ionizing radiation. Three groups of rats (five in each group) were intravenously injected with 1601 ± 376, 10,846 ± 591 and 48,467 ± 2812 Bq of (210)Po in citrate form. A sham-exposed control group of five rats was intravenously injected with sterile physiological saline. Daily urine samples were collected over 4 days following injection. Purification and pre-concentration of urinary proteins were carried out by ultrafiltration using a 3000 Da molecular weight cutoff membrane filter. The concentration of common urinary proteins, namely albumin, alpha-1-acid glycoprotein, immunoglobulins IgA and IgG, was measured by an enzyme-linked immunosorbent assay. Urinary excretion of albumin decreased dose-dependently (p < 0.05) 96 h post-injection relative to the control group. In contrast, no statistically significant effects were observed for other proteins tested. The dose-dependent decrease in urinary excretion of albumin observed in this study underscores the need for further research, which may lead to the discovery of new biomarkers that would reflect the changes in the primary target organs for deposition of (210)Po.

Indexed as

AmidohydrolasesAnimalsBiomarkersEnvironmental MonitoringEnzyme-Linked Immunosorbent AssayMalePoloniumProteinuriaRatsRats, WistarUltrafiltrationAmidohydrolasesBiomarkerscreatininasePoloniumBiomarkersInternal exposurePolonium-210Urinary proteins

Identifiers

PMID26961776
OpenAlexW2293281934

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.