ArticleGenome biology and evolution2016
Ancient Duplications Have Led to Functional Divergence of Vitellogenin-Like Genes Potentially Involved in Inflammation and Oxidative Stress in Honey Bees.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 69 citations in OpenAlex.
- A propolis-rich hive environment affects redox gene expression and gut microbiota at the individual and social level in honey bees.FEMS microbes · 2026Article
- Vitellogenin plays a role in regulating honey bee swarming.Scientific reports · 2025Article
- Evidence for vitellogenin DNA-binding in honey bees.Protein science : a publication of the Protein Society · 2025Article
- Antioxidant Potential of Pollen Polyphenols in Mitigating Environmental Stress in Honeybees (Antioxidants (Basel, Switzerland) · 2025Review
- Genomic signatures associated with the evolutionary loss of egg yolk in parasitoid wasps.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Climate change-induced stress in the honey beeFrontiers in physiology · 2025Review
- Conserved and Unique Protein Expression Patterns Across Reproductive Stage Transitions in Social Hymenopteran Queens.Molecular ecology · 2024Article
- A comparison of the large-scale gene expression patterns in summer and fall migratoryEcology and evolution · 2024Article
- The Effects of Artificial Diets on the Expression of Molecular Marker Genes Related to Honey Bee Health.International journal of molecular sciences · 2024Article
- Sex-Biased Transcription Expression of Vitellogenins Reveals Fusion Gene and MicroRNA Regulation in the Sea Louse Caligus rogercresseyi.Marine biotechnology (New York, N.Y.) · 2024Article
- Leafhopper salivary vitellogenin mediates virus transmission to plant phloem.Nature communications · 2024Article
- Cold storage as part of a Varroa management strategy: effects on honey bee colony performance, mite levels and stress biomarkers.Scientific reports · 2023Article
- Article
- Early Queen Development in Honey Bees: Social Context and Queen Breeder Source Affect Gut Microbiota and Associated Metabolism.Microbiology spectrum · 2022Article
- Changes in gut microbiota and metabolism associated with phenotypic plasticity in the honey beeFrontiers in microbiology · 2022Article
- Nuclear translocation of vitellogenin in the honey bee (Apidologie · 2022Article
- Molecular evolution of bumble bee vitellogenin and vitellogenin-like genes.Ecology and evolution · 2021Article
- Reproductive activation in honeybee (Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Young but not defenceless: antifungal activity during embryonic development of a social insect.Royal Society open science · 2020Article
- Honey bee colony performance and health are enhanced by apiary proximity to US Conservation Reserve Program (CRP) lands.Scientific reports · 2019Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protection against inflammation and oxidative stress is key in slowing down aging processes. The honey bee (Apis mellifera) shows flexible aging patterns linked to the social role of individual bees. One molecular factor associated with honey bee aging regulation is vitellogenin, a lipoglycophosphoprotein with anti-inflammatory and antioxidant properties. Recently, we identified three genes in Hymenopteran genomes arisen from ancient insect vitellogenin duplications, named vg-like-A, -B, and -C. The function of these vitellogenin homologs is unclear. We hypothesize that some of them might share gene- and protein-level similarities and a longevity-supporting role with vitellogenin. Here, we show how the structure and modifications of the vg-like genes and proteins have diverged from vitellogenin. Furthermore, all three vg-like genes show signs of positive selection, but the spatial location of the selected protein sites differ from those found in vitellogenin. We show that all these genes are expressed in both long-lived winter worker bees and in summer nurse bees with intermediate life expectancy, yet only vg-like-A shows elevated expression in winter bees as found in vitellogenin. Finally, we show that vg-like-A responds more strongly than vitellogenin to inflammatory and oxidative conditions in summer nurse bees, and that also vg-like-B responds to oxidative stress. We associate vg-like-A and, to lesser extent, vg-like-B to the antiaging roles of vitellogenin, but that vg-like-C probably is involved in some other function. Our analysis indicates that an ancient duplication event facilitated the adaptive and functional divergence of vitellogenin and its paralogs in the honey bee.
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