Evidence map›Paper›PMID 26961180›Full record

ArticleToxicologic pathology2016

Histology Atlas of the Developing Mouse Hepatobiliary Hemolymphatic Vascular System with Emphasis on Embryonic Days 11.5-18.5 and Early Postnatal Development.

Olivia M Swartley, Julie F Foley, David P Livingston, John M Cullen, Susan A Elmore

Open access · bronzeAbstract read
In one paragraph

Article in Toxicologic pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Defining a Midgestational Window forbioRxiv : the preprint server for biology · 2026
    Article
  3. Bioengineered Bile Duct for Liver Regenerative Medicine and Bile Duct Reconstruction.JGH open : an open access journal of gastroenterology and hepatology · 2025
    Review
  4. Article
  5. Spatiotemporal dynamics of fetal liver hematopoietic niches.The Journal of experimental medicine · 2025
    Article
  6. Review
  7. Generation ofRegenerative therapy · 2024
    Review
  8. Article
  9. Fetal liver development and implications for liver disease pathogenesis.Nature reviews. Gastroenterology & hepatology · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Olivia M SwartleyCollege of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Julie F FoleyCellular and Molecular Pathology Branch, National Toxicology Program, NIEHS, NIH, Research Triangle Park, North Carolina, USA.
David P LivingstonUSDA, Washington, DC, USA North Carolina State University, Raleigh, North Carolina, USA.
John M CullenCollege of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Susan A ElmoreCellular and Molecular Pathology Branch, National Toxicology Program, NIEHS, NIH, Research Triangle Park, North Carolina, USA elmore@niehs.nih.gov.
North Carolina State University · USNational Institute of Environmental Health Sciences · US

Funding

Interdisciplinary Biomedical Research Training ProgramT35OD011070 · OD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Ronald Hak Long Li · 2012 to 2026
$1.1M
Intramural NIH HHS Z99 ES999999NIH HHS T35 OD011070
6 · The paper itself

Abstract

A critical event in embryo development is the proper formation of the vascular system, of which the hepatobiliary system plays a pivotal role. This has led researchers to use transgenic mice to identify the critical steps involved in developmental disorders associated with the hepatobiliary vascular system. Vascular development is dependent upon normal vasculogenesis, angiogenesis, and the transformation of vessels into their adult counterparts. Any alteration in vascular development has the potential to cause deformities or embryonic death. Numerous publications describe specific stages of vascular development relating to various organs, but a single resource detailing the stage-by-stage development of the vasculature pertaining to the hepatobiliary system has not been available. This comprehensive histology atlas provides hematoxylin & eosin and immunohistochemical-stained sections of the developing mouse blood and lymphatic vasculature with emphasis on the hepatobiliary system between embryonic days (E) 11.5-18.5 and the early postnatal period. Additionally, this atlas includes a 3-dimensional video representation of the E18.5 mouse venous vasculature. One of the most noteworthy findings of this atlas is the identification of the portal sinus within the mouse, which has been erroneously misinterpreted as the ductus venosus in previous publications. Although the primary purpose of this atlas is to identify normal hepatobiliary vascular development, potential embryonic abnormalities are also described.

Indexed as

Anatomy, ArtisticAnimalsAtlases as TopicBiliary TractBlood VesselsEmbryo, MammalianEmbryonic DevelopmentLiverLymphatic SystemMiceMice, Transgenicatlasembryohepatobiliary developmentlymphatic developmentmouseportal sinusvascular development

Identifiers

PMID26961180
PMCPMC4912388
OpenAlexW2296300129

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.